Aminoglycoside antibiotics are used as prophylaxis, or urgent treatment, for many life-
threatening bacterial infections, including tuberculosis, sepsis, respiratory infections in cystic …

Fungal infections impact the lives of at least 12 million people every year, killing over 1.5
million. Wide-spread use of fungicides and prophylactic antifungal therapy have driven …

In the recent past, prevalence of life threatening fungal diseases have increased rapidly in
immune-compromised cases such as acquired immunodeficiency syndrome (AIDS), cancer …

Azoles are antifungal drugs used to treat fungal infections such as candidiasis in humans.
Their extensive use has led to the emergence of drug resistance, complicating antifungal …

A systematic analysis of all synthetic and chemoenzymatic methodologies for the
preparation of aminoglycosides for a variety of applications (therapeutic and agricultural) …

The emerging resistance of crop pathogens to fungicides poses a challenge to food security
and compels discovery of new antifungal compounds. Here, we show that mono-alkyl …

Cationic amphiphiles derived from aminoglycosides (AGs) have been shown to exhibit
enhanced antimicrobial activity. Through the attachment of hydrophobic residues such as …

Fungal pathogens cause over 6.5 million life-threatening systemic infections annually, with
mortality rates ranging from 20 to 95%, even with medical intervention. The World Health …

Fluconazole (FLC) is the drug of choice when it comes to treat fungal infections such as
invasive candidiasis in humans. However, the widespread use of FLC has resulted in the …

In this study, we investigated the in vitro antifungal activities, cytotoxicities, and membrane-
disruptive actions of amphiphilic tobramycin (TOB) analogues. The antifungal activities were …