Engineering lactate-modulating nanomedicines for cancer therapy

J Chen, Y Zhu, C Wu, J Shi - Chemical Society Reviews, 2023 - pubs.rsc.org
Lactate in tumors has long been considered “metabolic junk” derived from the glycolysis of
cancer cells and utilized only as a biomarker of malignancy, but is presently believed to be a …

Tumor microenvironment-activated NIR-II reagents for tumor imaging and therapy

X Zhang, L An, Q Tian, J Lin, S Yang - Journal of Materials Chemistry …, 2020 - pubs.rsc.org
Second near-infrared window (NIR-II, 1000–1700 nm) absorption and fluorescent agents
have attracted great attention because they can overcome the penetration limitation of the …

Europium- and Black Phosphorus-Functionalized Porphyrin as an l-Arginine Sensor and l-Arginine-Activated PDT/PTT Agent for Bacterial Treatment

J Wang, F Chen, QY Chen… - ACS Applied Materials & …, 2023 - ACS Publications
The attenuation of bacterial metabolism provides an adjunct to the treatment of bacterial
infections. To develop a bacterial eradication agent, a bioactivatable material (BP@ Eu …

Current advances on nanomaterials interfering with lactate metabolism for tumor therapy

Q Cheng, XL Shi, QL Li, L Wang, Z Wang - Advanced Science, 2024 - Wiley Online Library
Increasing numbers of studies have shown that tumor cells prefer fermentative glycolysis
over oxidative phosphorylation to provide a vast amount of energy for fast proliferation even …

Harnessing bioactive nanomaterials in modulating tumor glycolysis-associated metabolism

Z Gu, C Yu - Journal of Nanobiotechnology, 2022 - Springer
Glycolytic reprogramming is emerging as a hallmark of various cancers and a promising
therapeutic target. Nanotechnology is revolutionizing the anti-tumor therapeutic approaches …

Modulating hypoxia inducible factor‐1 by nanomaterials for effective cancer therapy

Y Sun, Z Zhou, S Yang, H Yang - … Reviews: Nanomedicine and …, 2022 - Wiley Online Library
Hypoxia, which is induced by abnormal tumor growth when it outstrips its oxygen supply, is a
major character of cancer. The reaction of cells against hypoxia is mainly concentrated on …

[HTML][HTML] Harnessing glucose metabolism with nanomedicine for cancer treatment

X Wang, L Wang, Q Hao, M Cai, X Wang, W An - Theranostics, 2024 - pmc.ncbi.nlm.nih.gov
The significance of metabolic processes in cancer biology has garnered substantial
attention, as they are essential for meeting the anabolic demands and maintaining the redox …

Metal-polymer nanoconjugates application in cancer imaging and therapy

AQ Figueiredo, CF Rodrigues, N Fernandes… - Nanomaterials, 2022 - mdpi.com
Metallic-based nanoparticles present a unique set of physicochemical properties that
support their application in different fields, such as electronics, medical diagnostics, and …

[HTML][HTML] Glycolysis-based drug delivery nanosystems for therapeutic use in tumors and applications

C Geng, S Pang, R Ye, J Shi, Q Yang, C Chen… - Biomedicine & …, 2023 - Elsevier
Tumor cells are able to use glycolysis to produce energy under hypoxic conditions, and
even under aerobic conditions, they rely mainly on glycolysis for energy production, the …

[HTML][HTML] Microfluidic technologies in tumour metabolism

M Doherty, T Wang, DA Lamprou, JA Coulter - International Journal of …, 2022 - Elsevier
The tumour microenvironment presents many challenges in the development and evaluation
of new anti-cancer therapeutics. Enhanced understanding of the unique metabolic …