Sirtuin is an essential factor that delays cellular senescence and extends the organismal
lifespan through the regulation of diverse cellular processes. Suppression of cellular …

Dietary restriction (DR) is the most robust environmental manipulation known to increase
active and healthy lifespan in many species. Despite differences in the protocols and the …

Increasing evidence indicates that reactive oxygen species (ROS), consisting of superoxide,
hydrogen peroxide, and multiple others, do not only cause oxidative stress, but rather may …

When the food intake of organisms such as yeast and rodents is reduced (dietary restriction),
they live longer than organisms fed a normal diet. A similar effect is seen when the activity of …

Acetyl-CoA is a metabolite at the crossroads of central metabolism and the substrate of
histone acetyltransferases regulating gene expression. In many tissues fasting or lifespan …

Saccharomyces cerevisiae has directly or indirectly contributed to the identification of
arguably more mammalian genes that affect aging than any other model organism. Aging in …

Various nutritional, behavioral, and pharmacological interventions have been previously
shown to extend life span in diverse model organisms, including Saccharomyces cerevisiae …

Recent evidence suggests that calorie restriction and specifically reduced glucose
metabolism induces mitochondrial metabolism to extend life span in various model …

Adaptive homeostasis is “the transient expansion or contraction of the homeostatic range for
any given physiological parameter in response to exposure to sub‐toxic, non‐damaging …

Autophagy is an evolutionally conserved cytoplasmic degradation system in which varieties
of materials are sequestered by a double membrane structure, autophagosome, and …