Environmental chemical exposures and mitochondrial dysfunction: a review of recent literature
Abstract Purpose of Review Mitochondria play various roles that are important for cell
function and survival; therefore, significant mitochondrial dysfunction may have chronic …
function and survival; therefore, significant mitochondrial dysfunction may have chronic …
[HTML][HTML] Mitochondrial DNA heteroplasmy in the emerging field of massively parallel sequencing
Long an important and useful tool in forensic genetic investigations, mitochondrial DNA
(mtDNA) typing continues to mature. Research in the last few years has demonstrated both …
(mtDNA) typing continues to mature. Research in the last few years has demonstrated both …
Extensive pathogenicity of mitochondrial heteroplasmy in healthy human individuals
A majority of mitochondrial DNA (mtDNA) mutations reported to be implicated in diseases
are heteroplasmic, a status with coexisting mtDNA variants in a single cell. Quantifying the …
are heteroplasmic, a status with coexisting mtDNA variants in a single cell. Quantifying the …
The use of museum specimens with high-throughput DNA sequencers
Natural history collections have long been used by morphologists, anatomists, and
taxonomists to probe the evolutionary process and describe biological diversity. These …
taxonomists to probe the evolutionary process and describe biological diversity. These …
Assessing mitochondrial DNA variation and copy number in lymphocytes of~ 2,000 Sardinians using tailored sequencing analysis tools
DNA sequencing identifies common and rare genetic variants for association studies, but
studies typically focus on variants in nuclear DNA and ignore the mitochondrial genome. In …
studies typically focus on variants in nuclear DNA and ignore the mitochondrial genome. In …
Unrevealed mosaicism in the next-generation sequencing era
M Gajecka - Molecular genetics and genomics, 2016 - Springer
Mosaicism refers to the presence in an individual of normal and abnormal cells that are
genotypically distinct and are derived from a single zygote. The incidence of mosaicism …
genotypically distinct and are derived from a single zygote. The incidence of mosaicism …
High-frequency and functional mitochondrial DNA mutations at the single-cell level
Decline in mitochondrial function underlies aging and age-related diseases, but the role of
mitochondrial DNA (mtDNA) mutations in these processes remains elusive. To investigate …
mitochondrial DNA (mtDNA) mutations in these processes remains elusive. To investigate …
High-throughput sequencing in mitochondrial DNA research
F Ye, DC Samuels, T Clark, Y Guo - Mitochondrion, 2014 - Elsevier
Next-generation sequencing, also known as high-throughput sequencing, has greatly
enhanced researchers' ability to conduct biomedical research on all levels. Mitochondrial …
enhanced researchers' ability to conduct biomedical research on all levels. Mitochondrial …
[HTML][HTML] Full mtGenome reference data: Development and characterization of 588 forensic-quality haplotypes representing three US populations
RS Just, MK Scheible, SA Fast… - Forensic Science …, 2015 - Elsevier
Though investigations into the use of massively parallel sequencing technologies for the
generation of complete mitochondrial genome (mtGenome) profiles from difficult forensic …
generation of complete mitochondrial genome (mtGenome) profiles from difficult forensic …
Mitochondrial genome architecture in non‐alcoholic fatty liver disease
S Sookoian, D Flichman, R Scian, C Rohr… - The Journal of …, 2016 - Wiley Online Library
Non‐alcoholic fatty liver disease (NAFLD) is associated with mitochondrial dysfunction, a
decreased liver mitochondrial DNA (mtDNA) content, and impaired energy metabolism. To …
decreased liver mitochondrial DNA (mtDNA) content, and impaired energy metabolism. To …