mRNA vaccines in disease prevention and treatment

G Zhang, T Tang, Y Chen, X Huang… - Signal transduction and …, 2023 - nature.com
Abstract mRNA vaccines have emerged as highly effective strategies in the prophylaxis and
treatment of diseases, thanks largely although not totally to their extraordinary performance …

[HTML][HTML] Therapeutic strategies for liver diseases based on redox control systems

J Lee, J Kim, R Lee, E Lee, TG Choi, AS Lee… - Biomedicine & …, 2022 - Elsevier
In the liver, reactive oxygen species (ROS) are constantly released during cellular metabolic
processes, and excess ROS production can cause redox stress. The redox stress is both …

mRNA-based approaches to treating liver diseases

ML Cacicedo, MJ Limeres, S Gehring - Cells, 2022 - mdpi.com
Diseases that affect the liver account for approximately 2 million deaths worldwide each
year. The increasing prevalence of these diseases and the limited efficacy of current …

Lipid nanoparticles as the drug carrier for targeted therapy of hepatic disorders

R Chu, Y Wang, J Kong, T Pan, Y Yang… - Journal of Materials …, 2024 - pubs.rsc.org
The liver, a complex and vital organ in the human body, is susceptible to various diseases
that have emerged as significant contributors to global morbidity and mortality over recent …

[PDF][PDF] A look into hemostatic characteristics during pediatric liver transplantation using the thromboelastometry (ROTEM®) test

JK Cho, YJ Moon, IK Song, EJ Kang… - Liver …, 2022 - Wiley Online Library
There is a paucity of evidence about the coagulation profile regarding the complexity of
children undergoing liver transplantation (LT). This study aimed to investigate intraoperative …

Impact of citrulline substitution on clinical outcome after liver transplantation in carbamoyl phosphate synthetase 1 and ornithine transcarbamylase deficiency

D Aldrian, B Waldner, GF Vogel… - Journal of inherited …, 2024 - Wiley Online Library
Abstract Carbamoyl phosphate synthetase 1 (CPS1) and ornithine transcarbamylase (OTC)
deficiencies are rare urea cycle disorders, which can lead to life‐threatening …

Liver transplantation for pediatric genetic and metabolic disorders

S Hassan, A Anouti, QKG Tan… - Liver …, 2024 - journals.lww.com
Pediatric genetic and metabolic liver diseases comprise a broad spectrum of conditions and
represent the second most common indication for liver transplantation following biliary …

Identification of a biallelic MMUT variant (p.Thr230Arg) and its global perspective on clinical management

S Mansoor, Q Ali, SA Khan, MI Malik, M Imran… - Molecular Biology …, 2025 - Springer
Background Methylmalonic acidemia (MMA), type mut (0) is a rare type of genetic inborn
error of metabolism (IEM) that is caused by aberrant malonyl-CoA mutase activity …

[PDF][PDF] Liver transplantation for congenital metabolic disorders

A Alim, İ Tirnova, C Karataş, A Akbulut… - Cerrahpaşa …, 2022 - cerrahpasamedj.org
Objective: The aim of the study is to identify the indications for and the outcomes of liver
transplantation in congenital metabolic diseases. Methods: Indications, survival, and …

[HTML][HTML] Not only a small liver-The pathologist's perspective in the pediatric liver transplant setting

A Gambella, L Mastracci, C Caporalini, P Francalanci… - Pathologica, 2022 - ncbi.nlm.nih.gov
Pediatric liver transplantation represents a safe and long-lasting treatment option for various
disease types, requiring the pathologist's input. Indeed, an accurate and timely diagnosis is …