Highlights on US FDA-approved fluorinated drugs over the past five years (2018–2022)

S Ali, J Zhou - European journal of medicinal chemistry, 2023 - Elsevier
The objective of this review is to provide an update on the fluorine-containing drugs
approved by US Food and Drug Administration in the span of past five years (2018–2022) …

[HTML][HTML] Human brain organoids as models for central nervous system viral infection

JA Depla, LA Mulder, RV de Sá, M Wartel, A Sridhar… - Viruses, 2022 - mdpi.com
Pathogenesis of viral infections of the central nervous system (CNS) is poorly understood,
and this is partly due to the limitations of currently used preclinical models. Brain organoid …

Allosteric inhibitors of the main protease of SARS-CoV-2

SK Samrat, J Xu, X Xie, E Gianti, H Chen, J Zou… - Antiviral research, 2022 - Elsevier
SARS-CoV-2 has raised the alarm to search for effective therapy for this virus. To date
several vaccines have been approved but few available drugs reported recently still need …

[HTML][HTML] Brain organoid: a 3D technology for investigating cellular composition and interactions in human neurological development and disease models in vitro

OS Agboola, X Hu, Z Shan, Y Wu, L Lei - Stem Cell Research & Therapy, 2021 - Springer
The study of human brain physiology, including cellular interactions in normal and disease
conditions, has been a challenge due to its complexity and unavailability. Induced …

[HTML][HTML] The magic bullet: Niclosamide

H Jiang, AM Li, J Ye - Frontiers in Oncology, 2022 - frontiersin.org
The term 'magic bullet'is a scientific concept proposed by the German Nobel laureate Paul
Ehrlich in 1907, describing a medicine that could specifically and efficiently target a disease …

[HTML][HTML] Repurposing of doramectin as a new anti-zika virus agent

Y Zhu, M Liang, J Yu, B Zhang, G Zhu, Y Huang, Z He… - Viruses, 2023 - mdpi.com
Zika virus (ZIKV), belonging to the Flavivirus family and mainly transmitted by mosquitoes,
causes a variety of adverse outcomes, including Guillain-Barré syndrome, microcephaly …

[HTML][HTML] Antiviral agents against flavivirus protease: prospect and future direction

SK Samrat, J Xu, Z Li, J Zhou, H Li - Pathogens, 2022 - mdpi.com
Flaviviruses cause a significant amount of mortality and morbidity, especially in regions
where they are endemic. A recent example is the outbreak of Zika virus throughout the …

Drug repurposing approach to combating coronavirus: Potential drugs and drug targets

J Xu, Y Xue, R Zhou, PY Shi, H Li… - Medicinal research …, 2021 - Wiley Online Library
In the past two decades, three highly pathogenic human coronaviruses severe acute
respiratory syndrome coronavirus (SARS‐CoV), Middle East respiratory syndrome …

NS2B‐NS3 protease inhibitors as promising compounds in the development of antivirals against Zika virus: A systematic review

DAF Nunes, FRS Santos… - Journal of Medical …, 2022 - Wiley Online Library
Zika virus (ZIKV) infections are associated with severe neurological complications and are a
global public health concern. There are no approved vaccines or antiviral drugs to inhibit …

[HTML][HTML] Niclosamide as a promising therapeutic player in human cancer and other diseases

Z Wang, J Ren, J Du, H Wang, J Liu… - International Journal of …, 2022 - mdpi.com
Niclosamide is an FDA-approved anthelmintic drug for the treatment of parasitic infections.
However, over the past few years, increasing evidence has shown that niclosamide could …