Large-scale cancer genome sequencing studies have revealed that chromatin regulators
are frequently mutated in cancer. In particular, more than 20% of cancers harbour mutations …

As epigenetic therapies continue to gain ground as potential treatment strategies for cancer
and other diseases, compounds that target histone lysine methylation and the enzyme …

Soft tissue sarcomas (STSs) are rare mesechymal malignancies characterized by distintive
molecular, histological and clinical features. Many STSs are considered as predominatly …

Recently, the fifth edition of the WHO classification recognized the thoracic SMARCA4-
deficient undifferentiated tumor (SMARCA4-UT) as a separate entity from conventional non …

Thoracic SMARCA4-deficient undifferentiated tumor is a newly recognized disease entity
characterized as a high-grade malignant neoplasm with an undifferentiated or rhabdoid …

Background We evaluate outcomes of SMARCB1‐deficient sinonasal carcinomas in the
largest single‐institution study. Methods Retrospective cross‐sectional study of patients with …

Purpose: Extracranial malignant rhabdoid tumors (eMRT) are a challenging entity. Despite
the use of multimodal treatment approaches, therapy failure occurs in 55% to 67% of these …

Renal medullary carcinoma is a rare undifferentiated tumor of the kidney associated with
sickle cell trait and characterized by INI1 (SMARCB1) loss. Although metastasis to lungs …

Ewing sarcoma (ES) is a malignant tumor of bone and soft tissue that most often occurs in
children, adolescents, and young adults. Debate and controversy remain in the …

Pediatric lymphoepithelioma-like carcinoma (pLELC) is a rare neoplasm with unclear
prognosis, genome, and tumor microenvironment. Our study aims to elucidate its genomic …