Late-life depression occurring in older adults is common, recurrent, and malignant. It is
characterized by affective symptoms, but also cognitive decline, medical comorbidity, and …

A decade has passed since we published a comprehensive review in this journal
addressing the topic of promoting successful cognitive aging, making this a good time to …

Deficits in cognition, reward processing, and motor function are clinical features relevant to
both aging and depression. Individuals with late-life depression often show impairment …

Psychotherapy is a comprehensive biological treatment modifying complex underlying
cognitive, emotional, behavioral, and regulatory responses in the brain, leading patients with …

Depression is associated with markers of accelerated aging, but it is unclear how this
relationship changes across the lifespan. We examined whether a brain-based measure of …

Recent neuroimaging studies have characterized the pathophysiology of late-life depression
(LLD) as a dysfunction of the brain networks involved in the regulation of emotion …

Multiple structural and functional neuroimaging measures vary over the course of the
lifespan and can be used to predict chronological age. Accelerated brain aging, as …

Depression in older individuals is a common complex mood disorder with high comorbidity
of both psychiatric and physical diseases, associated with high disability, cognitive decline …

Background Late-life depression (LLD) is a common and serious mental disorder, whose
neural mechanisms are not yet fully understood. In this study, we aimed to characterize LLD …

Late-life depression (LLD) is a particularly debilitating illness. Older adults suffering from
depression commonly experience poor outcomes in response to antidepressant treatments …