N-acetylserotonin protects PC12 cells from hydrogen peroxide induced damage through ROS mediated PI3K/AKT pathway

J Kang, Y Wang, X Guo, X He, W Liu, H Chen, Z Wang… - Cell Cycle, 2022 - Taylor & Francis
ABSTRACT N-acetylserotonin (NAS) exerts neuroprotective, antioxidant, and anti-apoptotic
effects. Oxidative stress and apoptosis are the primary causes of spinal cord injury (SCI) …

Neuroprotective effects of N-acetylserotonin and its derivative

JH Kang, XD Guo, YD Wang, XW Kang - Neuroscience, 2023 - Elsevier
N-acetylserotonin (NAS) is a chemical intermediate in melatonin biosynthesis. NAS and its
derivative N-(2-(5-hydroxy-1H-indol-3-yl) ethyl)-2-oxopiperidine-3-carboxamide (HIOC) are …

Disruption of melatonin synthesis is associated with impaired 14-3-3 and miR-451 levels in patients with autism spectrum disorders

C Pagan, H Goubran-Botros, R Delorme, M Benabou… - Scientific reports, 2017 - nature.com
Autism spectrum disorders (ASD) are characterized by a wide genetic and clinical
heterogeneity. However, some biochemical impairments, including decreased melatonin …

Melatonin reverts methamphetamine-induced learning and memory impairments and hippocampal alterations in mice

N Veschsanit, JL Yang, S Ngampramuan, K Viwatpinyo… - Life sciences, 2021 - Elsevier
Aims Methamphetamine (METH) has become a major public health problem because of its
abuse and profound neurotoxic effects, causing alterations in brain structure and function …

RNA-Seq approach to investigate the effects of melatonin on bone marrow-derived dendritic cells from dextran sodium sulfate-induced colitis mice

S Feng, Z Xu, Z Zhang, Y Mo, Y Deng, L Li, S Fei, J Wu… - Toxicology, 2022 - Elsevier
Melatonin (MLT) was reported to have therapeutic effects on inflammatory bowel disease
(IBD) such as ulcerative colitis (UC) and Crohn's disease (CD) due to its anti-inflammatory …

[HTML][HTML] Blood platelet research in autism spectrum disorders: In search of biomarkers

M Padmakumar, E Van Raes, C Van Geet… - Research and practice in …, 2019 - Elsevier
Autism spectrum disorder (ASD) is a clinically heterogeneous neurodevelopmental disorder
that is caused by gene‐environment interactions. To improve its diagnosis and treatment …

Putative neuroprotective pharmacotherapies to target the staged progression of mental illness

OD Robertson, NG Coronado, R Sethi… - Early intervention in …, 2019 - Wiley Online Library
Aim Neuropsychiatric disorders including depression, bipolar and schizophrenia frequently
exhibit a neuroprogressive course from prodrome to chronicity. There are a range of agents …

Protective effects of melatonin on neurogenesis impairment in neurological disorders and its relevant molecular mechanisms

JWH Leung, KK Cheung, SPC Ngai… - International journal of …, 2020 - mdpi.com
Neurogenesis is the process by which functional new neurons are generated from the
neural stem cells (NSCs) or neural progenitor cells (NPCs). Increasing lines of evidence …

Dysregulation of circadian rhythms in autism spectrum disorders

L Pinato, CS Galina Spilla, RP Markus… - Current …, 2019 - ingentaconnect.com
Background: The alterations in neurological and neuroendocrine functions observed in the
autism spectrum disorder (ASD) involves environmentally dependent dysregulation of …

[HTML][HTML] Ketamine administered pregnant rats impair learning and memory in offspring via the CREB pathway

X Li, C Guo, Y Li, L Li, Y Wang, Y Zhang, Y Li, Y Chen… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Ketamine has been reported to impair the capacity for learning and memory. This study
examined whether these capacities were also altered in the offspring and investigated the …