Monocyte chemoattractant protein-1 (MCP-1/CCL2) is renowned for its ability to drive the
chemotaxis of myeloid and lymphoid cells. It orchestrates the migration of these cell types …

Decades of research have established atherosclerosis as an inflammatory disease. Only
recently though, clinical trials provided proof-of-concept evidence for the efficacy of anti …

Mast cells are well known for their role in allergic and anaphylactic reactions, as well as their
involvement in acquired and innate immunity. Increasing evidence now implicates mast cells …

Chemokines regulate inflammation, leukocyte trafficking, and immune cell differentiation.
The role of chemokines in homing of naive T lymphocytes to secondary lymphatic organs is …

Mast cells are well known for their involvement in allergic and anaphylactic reactions, during
which immunoglobulin E (IgE) receptor (FcɛRI) aggregation leads to exocytosis of the …

Mast cells are not only necessary for allergic reactions, but recent findings indicate that they
are also involved in a variety of neuroinflammatory diseases, especially those worsened by …

Introduction: An increasing number of patients present with multiple symptoms affecting
many organs including the brain due to multiple mediators released by mast cells. These …

Accumulation of mast cells (MCs) in tumours was described by Ehrlich in his doctoral thesis.
Since this early account, ample evidence has been provided highlighting participation of …

Mast cells accumulate in the stroma surrounding certain tumors, especially mammary
adenocarcinoma, and molecules they secrete could benefit the tumor. These include …

Mast cells are well known for their involvement in allergic and anaphylactic reactions, but
recent findings implicate them in a variety of inflammatory diseases affecting different …