Stroke is the second highest cause of death globally and a leading cause of disability, with
an increasing incidence in developing countries. Ischaemic stroke caused by arterial …

Background Stroke thrombolysis with alteplase is currently recommended 0–4· 5 h after
stroke onset. We aimed to determine whether perfusion imaging can identify patients with …

Intravenous thrombolysis is the only approved systemic reperfusion treatment for patients
with acute ischaemic stroke. These European Stroke Organisation (ESO) guidelines provide …

Lacunar infarcts represent one of the most frequent subtypes of ischemic strokes and may
represent the first recognizable manifestation of a progressive disease of the small …

Background Patients who have had a stroke with unknown time of onset have been
previously excluded from thrombolysis. We aimed to establish whether intravenous …

Background Occlusion of a cerebral blood vessel causes a variable decrease of blood flow
in the downstream parenchyma proportionate to the degree of collateral circulation. In brain …

Background Current evidence supports the use of intravenous thrombolysis with alteplase in
patients with wake-up stroke selected with MRI or perfusion imaging and is recommended in …

Stroke is a leading cause of morbidity and mortality in the United States. Whether
hemorrhagic or ischemic, stroke leads to severe long-term disability. Prior to the mid-1990s …

Background and Objectives To determine the rate and predictors of early neurologic
deterioration (END) in patients with lacunar strokes and its implications for management and …

Background and Purpose—We assessed whether lower-dose alteplase at 0.6 mg/kg is
efficacious and safe for acute fluid-attenuated inversion recovery-negative stroke with …