Mating type in Saccharomyces cerevisiae is determined by two nonhomologous alleles,
MAT a and MAT α. These sequences encode regulators of the two different haploid mating …

DOT1 (disruptor of telomeric silencing; also called Kmt4) was initially discovered in budding
yeast in a genetic screen for genes whose deletion confers defects in telomeric silencing …

Expression of the type II voltage-dependent sodium channel gene is restricted to neurons by
a silencer element active in nonneuronal cells. We have cloned cDNA coding for a …

Genomic silencing is a fundamental mechanism of transcriptional regulation, yet little is
known about conserved mechanisms of silencing. We report here the discovery of four …

The Third Edition of Chromatin: Structure and Function brings the reader up-to-date with the
remarkable progress in chromatin research over the past three years. It has been …

Most cells cannot divide indefinitely due to a process termed cellular or replicative
senescence. Replicative senescence appears to be a fundamental feature of somatic cells …

Heterochromatin, defined by histone H3 lysine 9 methylation (H3K9me), spreads across
large domains and can be epigenetically inherited in a self-propagating manner …

The amino-terminal histone tails are subject to covalent post-translational modifications such
as acetylation, methylation, and phosphorylation. In the histone code hypothesis, these …

The silent mating loci and chromosomal regions adjacent to telomeres of S. cerevisiae have
features similar to heterochromatin of more complex eukaryotes. Transcriptional repression …

During development of T lymphocytes, differential regulation of expression of the CD4 and
CD8 glycoproteins is coupled to the choice of one of two pathways of differentiation …