Cellular rejuvenation: molecular mechanisms and potential therapeutic interventions for diseases

S Ji, M Xiong, H Chen, Y Liu, L Zhou, Y Hong… - … and Targeted Therapy, 2023 - nature.com
The ageing process is a systemic decline from cellular dysfunction to organ degeneration,
with more predisposition to deteriorated disorders. Rejuvenation refers to giving aged cells …

Dissecting aging and senescence—current concepts and open lessons

C Schmeer, A Kretz, D Wengerodt, M Stojiljkovic… - Cells, 2019 - mdpi.com
In contrast to the programmed nature of development, it is still a matter of debate whether
aging is an adaptive and regulated process, or merely a consequence arising from a …

[HTML][HTML] Aging Process and Related Diseases

F Taheri, E Rahmani, SS Fard, M Rezaei, A Ayati… - Kindle, 2023 - preferpub.org
The aging process is a complex biological phenomenon that results in the gradual decline of
physiological function and an increased risk of age-related diseases. While aging is a …

Mesenchymal stem cell senescence and rejuvenation: current status and challenges

X Zhou, Y Hong, H Zhang, X Li - Frontiers in Cell and Developmental …, 2020 - frontiersin.org
Over the past decades, mesenchymal stem cell (MSC)-based therapy has been intensively
investigated and shown promising results in the treatment of various diseases due to their …

Cellular senescence in the aging brain: a promising target for neurodegenerative diseases

MR Sahu, L Rani, R Subba, AC Mondal - Mechanisms of Ageing and …, 2022 - Elsevier
Aging is inevitable. Along with reduced ability to maintain the homeostasis of various
biological processes, aging gradually deteriorates overall health. Extensive research on the …

The ground zero of organismal life and aging

VN Gladyshev - Trends in molecular medicine, 2021 - cell.com
Cells may naturally proceed or be forced to transition to a state with a radically lower
biological age, that is, be rejuvenated. Examples are the conversion of somatic cells to …

Emerging rejuvenation strategies—Reducing the biological age

B Zhang, A Trapp, C Kerepesi, VN Gladyshev - Aging Cell, 2022 - Wiley Online Library
Several interventions have recently emerged that were proposed to reverse rather than just
attenuate aging, but the criteria for what it takes to achieve rejuvenation remain …

A natural product solution to aging and aging-associated diseases

C Yang, W Zhang, X Dong, C Fu, J Yuan, M Xu… - Pharmacology & …, 2020 - Elsevier
Aging is a natural biological progress accompanied by the gradual decline in physiological
functions, manifested by its close association with an increased incidence of human …

Can blood-circulating factors unveil and delay your biological aging?

N Rybtsova, T Berezina, A Kagansky, S Rybtsov - Biomedicines, 2020 - mdpi.com
According to the World Health Organization, the population of over 60 will double in the next
30 years in the developed countries, which will enforce a further raise of the retirement age …

Age-related changes in bone-marrow mesenchymal stem cells

VA Babenko, DN Silachev, TI Danilina, KV Goryunov… - Cells, 2021 - mdpi.com
The use of stem cells is part of a strategy for the treatment of a large number of diseases.
However, the source of the original stem cells for use is extremely important and determines …