Background and Purpose—Magnesium sulfate is used extensively for prevention of
eclamptic seizures. Empirical and clinical evidence supports the effectiveness of magnesium …

The blood–brain barrier (BBB) is the main obstacle to the effective delivery of therapeutic
agents to the brain, compromising treatment efficacy for a variety of neurological disorders …

Cerebral palsy (CP) is a chronic childhood disorder with no effective cure.
Neuroinflammation, caused by activated microglia and astrocytes, plays a key role in the …

Encephalopathy due to reversible cerebral edema is an important cause of neurologic
morbidity accompanying many disorders. Although controversy remains concerning the …

Objective To investigate whether irisin could protect against blood–brain barrier (BBB)
dysfunction following focal cerebral ischemia/reperfusion in rats. Methods and Materials …

This study investigated the effects of streptozotocin-induced diabetes on the functional
integrity of the blood-brain barrier in the rat at 7, 28, 56, and 90 days, using vascular space …

Blood–brain barrier (BBB) constituted primarily by the capillary endothelial cells functions to
maintain a constant environment for the brain, by preventing or slowing down the passage of …

Eclampsia, defined as unexplained seizure in a woman with preeclampsia, is a life-
threatening complication of pregnancy with unclear etiology. Magnesium sulfate (MgSO4) is …

From a complications standpoint, diabetes mellitus is a disease of the vasculature. Diabetics
face a considerably higher risk of developing cardiovascular and cerebrovascular diseases …

The blood-brain barrier (BBB), a dynamic interface between blood and brain constituted
mainly by endothelial cells of brain microvessels, robustly restricts the entry of potentially …