Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs

G Cirino, C Szabo… - Physiological …, 2023 - journals.physiology.org
Over the last two decades, hydrogen sulfide (H2S) has emerged as an endogenous
regulator of a broad range of physiological functions. H2S belongs to the class of molecules …

[HTML][HTML] Hydrogen sulfide: An endogenous regulator of the immune system

N Dilek, A Papapetropoulos, T Toliver-Kinsky… - Pharmacological …, 2020 - Elsevier
Hydrogen sulfide (H 2 S) is now recognized as an endogenous signaling gasotransmitter in
mammals. It is produced by mammalian cells and tissues by various enzymes …

[HTML][HTML] Astrocyte-derived small extracellular vesicles promote synapse formation via fibulin-2-mediated TGF-β signaling

MR Patel, AM Weaver - Cell reports, 2021 - cell.com
Neuronal synapse formation is critical for brain development and depends on secreted
factors from astrocytes. Here, we report that small extracellular vesicles (EVs) secreted from …

Helicobacter pylori and the Role of Lipopolysaccharide Variation in Innate Immune Evasion

D Sijmons, AJ Guy, AK Walduck… - Frontiers in …, 2022 - frontiersin.org
Helicobacter pylori is an important human pathogen that infects half the human population
and can lead to significant clinical outcomes such as acute and chronic gastritis, duodenal …

H2S and reactive sulfur signaling at the host-bacterial pathogen interface

BJC Walsh, DP Giedroc - Journal of Biological Chemistry, 2020 - ASBMB
Bacterial pathogens that cause invasive disease in the vertebrate host must adapt to host
efforts to cripple their viability. Major host insults are reactive oxygen and reactive nitrogen …

Polyamines in gut epithelial renewal and barrier function

JN Rao, L Xiao, JY Wang - Physiology, 2020 - journals.physiology.org
Polyamines regulate a variety of physiological functions and are involved in pathogenesis of
diverse human diseases. The epithelium of the mammalian gut mucosa is a rapidly self …

[HTML][HTML] Cystathionine γ-lyase exacerbates Helicobacter pylori immunopathogenesis by promoting macrophage metabolic remodeling and activation

YL Latour, JC Sierra, JL Finley, M Asim, DP Barry… - JCI insight, 2022 - ncbi.nlm.nih.gov
Macrophages play a crucial role in the inflammatory response to the human stomach
pathogen Helicobacter pylori, which infects half of the world's population and causes gastric …

Protective application of Chinese herbal compounds and formulae in intestinal inflammation in humans and animals

Y Yang, G Xiao, P Cheng, J Zeng, Y Liu - Molecules, 2023 - mdpi.com
Intestinal inflammation is a chronic gastrointestinal disorder with uncertain pathophysiology
and causation that has significantly impacted both the physical and mental health of both …

Hypusination orchestrates the antimicrobial response of macrophages

AP Gobert, JL Finley, YL Latour, M Asim, TM Smith… - Cell reports, 2020 - cell.com
Innate responses of myeloid cells defend against pathogenic bacteria via inducible effectors.
Deoxyhypusine synthase (DHPS) catalyzes the transfer of the N-moiety of spermidine to the …

Hypoxia-inducible lipid droplet-associated protein (HILPDA) and cystathionine β-synthase (CBS) co-contribute to protecting intestinal epithelial cells from …

S Fu, R Yu, B Yang, X Han, Y Xu, J Miao - Biochimica et Biophysica Acta …, 2024 - Elsevier
Despite Staphylococcus aureus (S. aureus) being a highly studied zoontic bacterium, its
enteropathogenicity remains elusive. Herein, our findings demonstrated that S. aureus …