The perspectives of regenerative medicine are still severely hampered by the host response
to biomaterial implantation, despite the robustness of technologies that hold the promise to …

The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …

The development, maintenance of healthy bone and regeneration of injured tissue in the
human body comprise a set of intricate and finely coordinated processes. However, an …

Osseointegration of implants is a complex physiological process that requires temporal and
spatial regulation of immune responses, angiogenesis, and osteogenesis. To achieve …

Calcium phosphate ceramics (CPCs) have been widely used as biomaterials for the
regeneration of bone tissue because of their ability to induce osteoblastic differentiation in …

A key for long-term survival and function of biomaterials is that they do not elicit a detrimental
immune response. As biomaterials can have profound impacts on the host immune …

The foreign body reaction composed of macrophages and foreign body giant cells is the end-
stage response of the inflammatory and wound healing responses following implantation of …

Cell transplantation holds immense potential for reversing diseases that are currently
incurable and for regenerating tissues. However, poor cell survival, cell aggregation and …

Osteoimmunomodulation has informed the importance of modulating a favorable
osteoimmune environment for successful materials-mediated bone regeneration …

Embryogenic developmental processes involve a tightly controlled regulation between
mechanical forces and biochemical cues such as growth factors, matrix proteins, and …