Preeclampsia: pathophysiology, challenges, and perspectives

S Rana, E Lemoine, JP Granger… - Circulation …, 2019 - Am Heart Assoc
Hypertensive disorders of pregnancy—chronic hypertension, gestational hypertension, and
preeclampsia—are uniquely challenging as the pathology and its therapeutic management …

Pre-eclampsia: pathogenesis, novel diagnostics and therapies

EA Phipps, R Thadhani, T Benzing… - Nature Reviews …, 2019 - nature.com
Pre-eclampsia is a complication of pregnancy that is associated with substantial maternal
and fetal morbidity and mortality. The disease presents with new-onset hypertension and …

[HTML][HTML] Imbalances in circulating angiogenic factors in the pathophysiology of preeclampsia and related disorders

S Rana, SD Burke, SA Karumanchi - American journal of obstetrics and …, 2022 - Elsevier
Preeclampsia is a devastating medical complication of pregnancy that can lead to significant
maternal and fetal morbidity and mortality. It is currently believed that there is abnormal …

Oxidative stress in preeclampsia and placental diseases

R Aouache, L Biquard, D Vaiman… - International journal of …, 2018 - mdpi.com
Preeclampsia is a persistent hypertensive gestational disease characterized by high blood
pressure and proteinuria, which presents from the second trimester of pregnancy. At the …

Preeclampsia beyond pregnancy: long-term consequences for mother and child

HR Turbeville, JM Sasser - American Journal of Physiology …, 2020 - journals.physiology.org
Preeclampsia is defined as new-onset hypertension after the 20th wk of gestation along with
evidence of maternal organ failure. Rates of preeclampsia have steadily increased over the …

Insulin resistance in COVID-19 and diabetes

N Govender, OP Khaliq, J Moodley, T Naicker - Primary Care Diabetes, 2021 - Elsevier
Background The epidemiology of COVID-19 and its association with cardiometabolic
disorders is poorly understood. This is a narrative review that investigates the effects of …

Preeclampsia: pathogenesis, prevention, and long-term complications

B Jim, SA Karumanchi - Seminars in nephrology, 2017 - Elsevier
Preeclampsia continues to afflict 5% to 8% of all pregnancies throughout the world and is
associated with significant morbidity and mortality to the mother and the fetus. Although the …

Preeclampsia: novel mechanisms and potential therapeutic approaches

Z Armaly, JE Jadaon, A Jabbour, ZA Abassi - Frontiers in physiology, 2018 - frontiersin.org
Preeclampsia is a serious complication of pregnancy where it affects 5–8% of all
pregnancies. It increases the morbidity and mortality of both the fetus and pregnant woman …

Circulating angiogenic factor levels in hypertensive disorders of pregnancy

R Thadhani, E Lemoine, S Rana… - NEJM …, 2022 - evidence.nejm.org
Background Among women with hypertensive disorders of pregnancy, biomarkers may
stratify risk for developing preeclampsia with severe features (sPE). Methods Across 18 US …

Placental vesicles carry active endothelial nitric oxide synthase and their activity is reduced in preeclampsia

C Motta-Mejia, N Kandzija, W Zhang, V Mhlomi… - …, 2017 - Am Heart Assoc
Preeclampsia, a multisystem hypertensive disorder of pregnancy, is associated with
increased systemic vascular resistance. Placentae from patients with preeclampsia have …