Mesenchymal–epithelial transition in development and reprogramming
During organogenesis, epithelial cells can give rise to mesenchymal cells through epithelial–
mesenchymal transition. The reverse process, mesenchymal–epithelial transition (MET), can …
mesenchymal transition. The reverse process, mesenchymal–epithelial transition (MET), can …
Molecular changes underlying hypertrophic scarring following burns involve specific deregulations at all wound healing stages (inflammation, proliferation and …
M Čoma, L Fröhlichová, L Urban, R Zajíček… - International Journal of …, 2021 - mdpi.com
Excessive connective tissue accumulation, a hallmark of hypertrophic scaring, results in
progressive deterioration of the structure and function of organs. It can also be seen during …
progressive deterioration of the structure and function of organs. It can also be seen during …
Actin remodeling confers BRAF inhibitor resistance to melanoma cells through YAP/TAZ activation
The activation of transcriptional coactivators YAP and its paralog TAZ has been shown to
promote resistance to anti‐cancer therapies. YAP/TAZ activity is tightly coupled to actin …
promote resistance to anti‐cancer therapies. YAP/TAZ activity is tightly coupled to actin …
Probing the lithium-response pathway in hiPSCs implicates the phosphoregulatory set-point for a cytoskeletal modulator in bipolar pathogenesis
BTD Tobe, AM Crain, AM Winquist… - Proceedings of the …, 2017 - National Acad Sciences
The molecular pathogenesis of bipolar disorder (BPD) is poorly understood. Using human-
induced pluripotent stem cells (hiPSCs) to unravel such mechanisms in polygenic diseases …
induced pluripotent stem cells (hiPSCs) to unravel such mechanisms in polygenic diseases …
The SIN3A/HDAC corepressor complex functionally cooperates with NANOG to promote pluripotency
Although SIN3A is required for the survival of early embryos and embryonic stem cells
(ESCs), the role of SIN3A in the maintenance and establishment of pluripotency remains …
(ESCs), the role of SIN3A in the maintenance and establishment of pluripotency remains …
[HTML][HTML] Reprogramming barriers and enhancers: strategies to enhance the efficiency and kinetics of induced pluripotency
B Ebrahimi - Cell Regeneration, 2015 - Elsevier
Induced pluripotent stem cells are powerful tools for disease modeling, drug screening, and
cell transplantation therapies. These cells can be generated directly from somatic cells by …
cell transplantation therapies. These cells can be generated directly from somatic cells by …
How to reprogram human fibroblasts to neurons
Z Xu, S Su, S Zhou, W Yang, X Deng, Y Sun, L Li, Y Li - Cell & Bioscience, 2020 - Springer
Destruction and death of neurons can lead to neurodegenerative diseases. One possible
way to treat neurodegenerative diseases and damage of the nervous system is replacing …
way to treat neurodegenerative diseases and damage of the nervous system is replacing …
Chemical modulation of transcriptionally enriched signaling pathways to optimize the conversion of fibroblasts into neurons
Direct conversion of human somatic fibroblasts into induced neurons (iNs) allows for the
generation of functional neurons while bypassing any stem cell intermediary stages …
generation of functional neurons while bypassing any stem cell intermediary stages …
TFAP2C facilitates somatic cell reprogramming by inhibiting c-Myc-dependent apoptosis and promoting mesenchymal-to-epithelial transition
Y Wang, S Chen, Q Jiang, J Deng, F Cheng, Y Lin… - Cell death & …, 2020 - nature.com
Transcription factors are known to mediate the conversion of somatic cells to induced
pluripotent stem cells (iPSCs). Transcription factor TFAP2C plays important roles in the …
pluripotent stem cells (iPSCs). Transcription factor TFAP2C plays important roles in the …