Cyclic di-AMP signaling in bacteria
J Stülke, L Krüger - Annual review of microbiology, 2020 - annualreviews.org
The second messenger molecule cyclic di-AMP (c-di-AMP) is formed by many bacteria and
archaea. In many species that produce c-di-AMP, this second messenger is essential for …
archaea. In many species that produce c-di-AMP, this second messenger is essential for …
Making and breaking of an essential poison: the cyclases and phosphodiesterases that produce and degrade the essential second messenger cyclic di-AMP in …
FM Commichau, JL Heidemann, R Ficner… - Journal of …, 2019 - Am Soc Microbiol
Cyclic di-AMP is a second-messenger nucleotide that is produced by many bacteria and
some archaea. Recent work has shown that c-di-AMP is unique among the signaling …
some archaea. Recent work has shown that c-di-AMP is unique among the signaling …
(p) ppGpp: magic modulators of bacterial physiology and metabolism
W Steinchen, V Zegarra, G Bange - Frontiers in Microbiology, 2020 - frontiersin.org
When bacteria experience growth-limiting environmental conditions, the synthesis of the
hyperphosphorylated guanosine derivatives (p) ppGpp is induced by enzymes of the …
hyperphosphorylated guanosine derivatives (p) ppGpp is induced by enzymes of the …
A decade of research on the second messenger c-di-AMP
W Yin, X Cai, H Ma, L Zhu, Y Zhang… - FEMS microbiology …, 2020 - academic.oup.com
ABSTRACT Cyclic dimeric adenosine 3′, 5′-monophosphate (c-di-AMP) is an emerging
second messenger in bacteria and archaea that is synthesized from two molecules of ATP …
second messenger in bacteria and archaea that is synthesized from two molecules of ATP …
Cyclic di-AMP, a second messenger of primary importance: tertiary structures and binding mechanisms
J He, W Yin, MY Galperin, SH Chou - Nucleic acids research, 2020 - academic.oup.com
Cyclic diadenylate (c-di-AMP) is a widespread second messenger in bacteria and archaea
that is involved in the maintenance of osmotic pressure, response to DNA damage, and …
that is involved in the maintenance of osmotic pressure, response to DNA damage, and …
Purine nucleosides interfere with c-di-AMP levels and act as adjuvants to re-sensitize MRSA to β-lactam antibiotics
AC Nolan, MS Zeden, I Kviatkovski, C Campbell… - Mbio, 2023 - Am Soc Microbiol
The purine-derived signaling molecules c-di-AMP and (p) ppGpp control mecA/PBP2a-
mediated β-lactam resistance in methicillin-resistant Staphylococcus aureus (MRSA) raise …
mediated β-lactam resistance in methicillin-resistant Staphylococcus aureus (MRSA) raise …
The lost language of the RNA World
JW Nelson, RR Breaker - Science signaling, 2017 - science.org
The possibility of an RNA World is based on the notion that life on Earth passed through a
primitive phase without proteins, a time when all genomes and enzymes were composed of …
primitive phase without proteins, a time when all genomes and enzymes were composed of …
Metabolic reprogramming and altered cell envelope characteristics in a pentose phosphate pathway mutant increases MRSA resistance to β-lactam antibiotics
Central metabolic pathways control virulence and antibiotic resistance, and constitute
potential targets for antibacterial drugs. In Staphylococcus aureus the role of the pentose …
potential targets for antibacterial drugs. In Staphylococcus aureus the role of the pentose …
c-di-AMP: an essential molecule in the signaling pathways that regulate the viability and virulence of Gram-positive bacteria
Signal transduction pathways enable organisms to monitor their external environment and
adjust gene regulation to appropriately modify their cellular processes. Second messenger …
adjust gene regulation to appropriately modify their cellular processes. Second messenger …
A delicate connection: c-di-AMP affects cell integrity by controlling osmolyte transport
FM Commichau, J Gibhardt, S Halbedel… - Trends in …, 2018 - cell.com
Bacteria use second-messenger molecules to adapt to their environment. Several second
messengers, among them cyclic di-AMP (c-di-AMP), have been discovered and intensively …
messengers, among them cyclic di-AMP (c-di-AMP), have been discovered and intensively …