Cells and tissues can sense and react to the modifications of the physico-chemical
properties of the extracellular environment (ECM) through integrin-based adhesion sites and …

Chromosome segregation during cell division requires a bipolar mitotic spindle. Therefore,
how the spindle is formed, maintained, and functions is of fundamental importance for all …

During cell division, kinetochore microtubules (KMTs) provide a physical linkage between
the chromosomes and the rest of the spindle. KMTs in mammalian cells are organized into …

Kinesins are a diverse superfamily of microtubule-based motors that perform fundamental
roles in intracellular transport, cytoskeletal dynamics and cell division. These motors share a …

The primary goal of a dividing somatic cell is to accurately and equally segregate its genome
into two new daughter cells. In eukaryotes, this process is performed by a self-organized …

The kinesin-3 motor KIF1A functions in neurons, where its fast and superprocessive motility
facilitates long-distance transport, but little is known about its force-generating properties …

The mitotic spindle is a microtubule-based assembly that separates the chromosomes
during cell division. As the spindle is basically a mechanical micro machine, the …

Cells exert, sense, and respond to the different physical forces through diverse mechanisms
and translating them into biochemical signals. The adhesion of cells is crucial in various …

The microtubule (MT) cytoskeleton bipolarizes at the onset of mitosis to form the spindle. In
animal cells, the kinesin-5 Eg5 primarily drives this reorganization by actively sliding MTs …

Anaphase B spindle elongation is characterized by the sliding apart of overlapping
antiparallel interpolar (ip) microtubules (MTs) as the two opposite spindle poles separate …