Recent discoveries of basal extracellular Rickettsiales have illuminated divergent
evolutionary paths to host dependency in later-evolving lineages. Family Rickettsiaceae …

The ability to genetically manipulate a pathogen is fundamental to discovering factors
governing host–pathogen interactions at the molecular level and is critical for devising …

In adapting to the intracellular niche, obligate intracellular bacteria usually undergo a
reduction of genome size by eliminating genes not needed for intracellular survival. These …

Scrub typhus, a mite-borne infectious disease, is caused by Orientia tsutsugamushi. Despite
many attempts to develop a protective strategy, an effective preventive vaccine has not been …

The rickettsial human pathogen Orientia tsutsugamushi (Ot) is an obligate intracellular Gram-
negative bacterium with one of the most highly fragmented and repetitive genomes of any …

Obligate intracellular bacteria of the order Rickettsiales include important human pathogens.
However, our understanding of the biology of Rickettsia species is limited by challenges …

Obligate intracellular bacteria in the order Rickettsiales are transmitted by arthropod vectors
and cause life-threatening infections in humans and animals. While both type 1 and type 4 …

Vector-borne diseases are a leading cause of death worldwide and pose a substantial
unmet medical need. Pathogens binding to host extracellular proteins (the" exoproteome") …

Orientia tsutsugamushi a causal agent of scrub typhus, is an obligate intracellular bacterium
that, akin to other rickettsiae, is dependent on host cell-derived nutrients for survival and thus …

Scrub typhus is a poorly studied but life-threatening disease caused by the intracellular
bacterium Orientia tsutsugamushi (Ot). Cellular and humoral immunity in Ot-infected patients …