Diffuse gliomas represent a heterogeneous group of universally lethal brain tumors
characterized by minimally effective genotype-targeted therapies. Recent advances have …

Altered tissue mechanics and metabolism are defining characteristics of cancer that impact
not only proliferation but also migration. While migrating through a mechanically and …

Cancer metastasis is no longer viewed as a linear cascade of events but rather as a series
of concurrent, partially overlapping processes, as successfully metastasizing cells assume …

Metastasis remains the greatest challenge in the clinical management of cancer. Cell motility
is a fundamental and ancient cellular behaviour that contributes to metastasis and is …

Head and neck squamous cell carcinoma (HNSCC) includes a subset of cancers driven by
human papillomavirus (HPV). Here we use single-cell RNA-seq to profile both HPV-positive …

Glioblastoma multiforme (GBM) is a malignant astrocytoma of the central nervous system
associated with a median survival time of 15 months, even with aggressive therapy. This …

Glioblastoma remains one of the most lethal types of cancer, and is the most common brain
tumour in adults. In particular, tumour recurrence after surgical resection and radiation …

Tumors of glial origin consist of a core mass and a penumbra of invasive, single cells,
decreasing in numbers towards the periphery and still detectable several centimeters away …

Simple Summary Anti-PD-1/PD-L1 and anti-CTLA-4-based immune checkpoint blockade
(ICB) immunotherapy have recently emerged as a breakthrough in human cancer treatment …

Adult gliomas are aggressive brain tumours associated with low patient survival rates and
limited life expectancy. The most important hallmark of this type of tumour is its invasive …