The new WHO classification of adrenal cortical proliferations reflects translational advances
in the fields of endocrine pathology, oncology and molecular biology. By adopting a …

Primary aldosteronism (PA) is associated with higher cardiovascular morbidity and mortality
rates than essential hypertension. The Japan Endocrine Society (JES) has developed an …

The hypothalamus-pituitary-adrenal (HPA) axis plays an important role in primary
aldosteronism. Aldosterone biosynthesis is regulated not only by angiotensin II in the renin …

Peripheral 18-oxocortisol (18oxoF) level could contribute to the detection of aldosterone-
producing adenoma (APA) in patients with primary aldosteronism. However, peripheral …

Context Aldosterone biosynthesis is regulated principally by ACTH and gene mutations as
well as by angiotensin II and serum potassium. In addition, previous studies have reported …

In primary aldosteronism (PA) the differentiation of unilateral aldosterone-producing
adenomas (APA) from bilateral adrenal hyperplasia (BAH) is usually performed by adrenal …

Connshing syndrome (CoSh)(adrenal-related synchronous aldosterone (A) and cortisol (C)
excess) represents a distinct entity among PA (primary hyperaldosteronisms) named by W …

Mutated channelopathy could play important roles in the pathogenesis of aldosterone-
producing adenoma (APA). In this study, we identified a somatic mutation, KCNJ5 157 …

Purpose Thyroid disorders have been reported in hypercortisolism patients. Endogenous
Cushing's syndrome (CS) potentially complicates its metabolic sequelae. We investigated …

Primary aldosteronism (PA) usually accompanies suppressed plasma renin activity (PRA)
through a negative feedback mechanism. While some cases of PA with unsuppressed PRA …