Nanoparticle surface functionalization: how to improve biocompatibility and cellular internalization

G Sanità, B Carrese, A Lamberti - Frontiers in molecular biosciences, 2020 - frontiersin.org
The use of nanoparticles (NP) in diagnosis and treatment of many human diseases,
including cancer, is of increasing interest. However, cytotoxic effects of NPs on cells and the …

State of the art of anthocyanins: Antioxidant activity, sources, bioavailability, and therapeutic effect in human health

N Tena, J Martín, AG Asuero - Antioxidants, 2020 - mdpi.com
The antioxidant activity of anthocyanins in food is well known. Numerous antioxidant assays
have been proposed to measure the capacity of anthocyanins to prevent the oxidation …

Dietary effects of anthocyanins in human health: A comprehensive review

AC Gonçalves, AR Nunes, A Falcão, G Alves, LR Silva - Pharmaceuticals, 2021 - mdpi.com
In recent years, the consumption of natural-based foods, including beans, fruits, legumes,
nuts, oils, vegetables, spices, and whole grains, has been encouraged. This fact is …

Nrf2: a dark horse in Alzheimer's disease treatment

A Osama, J Zhang, J Yao, X Yao, J Fang - Ageing research reviews, 2020 - Elsevier
Abstract Alzheimer's disease (AD), an age-dependent neurodegenerative disorder, is the
main cause of dementia. Common hallmarks of AD include the amyloid β-peptide (Aβ) …

Targeting autophagy, oxidative stress, and ER stress for neurodegenerative disease treatment

Y Esmaeili, Z Yarjanli, F Pakniya, E Bidram… - Journal of Controlled …, 2022 - Elsevier
Protein homeostasis is a vital process for cell function and, therefore, disruption of the
molecular mechanisms involved in this process, such as autophagy, may contribute to …

The therapeutic potential of anthocyanins: current approaches based on their molecular mechanism of action

B Salehi, J Sharifi-Rad, F Cappellini, Ž Reiner… - Frontiers in …, 2020 - frontiersin.org
Anthocyanins are natural phenolic pigments with biological activity. They are well-known to
have potent antioxidant and antiinflammatory activity, which explains the various biological …

Shaping the Nrf2-ARE-related pathways in Alzheimer's and Parkinson's diseases

L Fão, SI Mota, AC Rego - Ageing Research Reviews, 2019 - Elsevier
A failure in redox homeostasis is a common hallmark of Alzheimer's Disease (AD) and
Parkinson's Disease (PD), two age-dependent neurodegenerative disorders (NDD), causing …

The signaling pathways, and therapeutic targets of antiviral agents: focusing on the antiviral approaches and clinical perspectives of anthocyanins in the management …

P Mohammadi Pour, S Fakhri, S Asgary… - Frontiers in …, 2019 - frontiersin.org
As the leading cause of death worldwide, viruses significantly affect global health. Despite
the rapid progress in human healthcare, there are few viricidal and antiviral therapies that …

Natural antioxidant compounds as potential pharmaceutical tools against neurodegenerative diseases

A Marino, M Battaglini, N Moles, G Ciofani - ACS omega, 2022 - ACS Publications
Natural antioxidants are a very large diversified family of molecules classified by activity
(enzymatic or nonenzymatic), chemical-physical properties (eg, hydrophilic or lipophilic) …

Antioxidant therapy in oxidative stress-induced neurodegenerative diseases: Role of nanoparticle-based drug delivery systems in clinical translation

A Ashok, SS Andrabi, S Mansoor, Y Kuang, BK Kwon… - Antioxidants, 2022 - mdpi.com
Free radicals are formed as a part of normal metabolic activities but are neutralized by the
endogenous antioxidants present in cells/tissue, thus maintaining the redox balance. This …