Roles and mechanisms of exosomal non-coding RNAs in human health and diseases

C Li, YQ Ni, H Xu, QY Xiang, Y Zhao, JK Zhan… - Signal transduction and …, 2021 - nature.com
Exosomes play a role as mediators of cell-to-cell communication, thus exhibiting pleiotropic
activities to homeostasis regulation. Exosomal non-coding RNAs (ncRNAs), mainly …

The evolving landscape of exosomes in neurodegenerative diseases: exosomes characteristics and a promising role in early diagnosis

S Rastogi, V Sharma, PS Bharti, K Rani… - International journal of …, 2021 - mdpi.com
Neurodegenerative diseases (ND) remains to be one of the biggest burdens on healthcare
systems and serves as a leading cause of disability and death. Alzheimer's disease (AD) is …

Epigenetics of Alzheimer's disease

M Nikolac Perkovic, A Videtic Paska, M Konjevod… - Biomolecules, 2021 - mdpi.com
There are currently no validated biomarkers which can be used to accurately diagnose
Alzheimer's disease (AD) or to distinguish it from other dementia-causing neuropathologies …

Diagnostic and therapeutic potential of exosomes in Alzheimer's disease

T Soares Martins, D Trindade, M Vaz… - Journal of …, 2021 - Wiley Online Library
Exosomes are small extracellular vesicles released by almost all cell types in physiological
and pathological conditions. The exosomal potential to unravel disease mechanisms, or to …

The role of exosomal microRNAs and oxidative stress in neurodegenerative diseases

X Wang, Y Zhou, Q Gao, D Ping, Y Wang… - Oxidative medicine …, 2020 - Wiley Online Library
Neurodegenerative diseases including Alzheimer's disease and Parkinson's disease are
aging‐associated diseases with irreversible damage of brain tissue. Oxidative stress is …

Circulating exosomal miRNA as diagnostic biomarkers of neurodegenerative diseases

L Wang, L Zhang - Frontiers in molecular neuroscience, 2020 - frontiersin.org
Neurodegenerative diseases (NDDs) are a group of diseases caused by chronic and
progressive degeneration of neural tissue. The main pathological manifestations are …

Harnessing the therapeutic potential of extracellular vesicles for biomedical applications using multifunctional magnetic nanomaterials

L Yang, KD Patel, C Rathnam, R Thangam, Y Hou… - Small, 2022 - Wiley Online Library
Extracellular vesicles (eg, exosomes) carrying various biomolecules (eg, proteins, lipids,
and nucleic acids) have rapidly emerged as promising platforms for many biomedical …

Research progress on the role of extracellular vesicles in neurodegenerative diseases

Z Li, X Wang, X Wang, X Yi, YK Wong, J Wu… - Translational …, 2023 - Springer
Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease,
amyotrophic lateral sclerosis, and Huntington's disease, affect millions of people worldwide …

Cerebrospinal fluid biomarkers of Alzheimer's disease: current evidence and future perspectives

DA McGrowder, F Miller, K Vaz, C Nwokocha… - Brain sciences, 2021 - mdpi.com
Alzheimer's disease is a progressive, clinically heterogeneous, and particularly complex
neurodegenerative disease characterized by a decline in cognition. Over the last two …

Exposure to a mixture of heavy metals induces cognitive impairment: genes and microRNAs involved

HD Nguyen, MS Kim - Toxicology, 2022 - Elsevier
Converging evidence demonstrates that microRNAs (miRNAs) play an important role in the
etiology of cognitive impairment. Thus, we aim to:(i) identify the molecular mechanisms of …