Background n-of-1 trials are a type of crossover trial designed to optimise the evaluation of
health technologies in individual patients. This trial design may be considered for the …

The term 'data science'usually refers to the process of extracting value from big data
obtained from a large group of individuals. An alternative rendition, which we call …

This article, an introduction to HDSR's “Personalized (N-of-1) Trials: Methods, Applications,
and Impact” special issue, describes the rationale for a primer of the methods, data types …

Observational studies are notoriously susceptible to bias, and parallel-group randomized
trials are important to identify the best overall treatment for eligible patients. Yet, such trials …

Traditionally, studies in experimental physiology have been conducted in small groups of
human participants, animal models or cell lines. Important challenges include achieving …

An N-of-1 trial is a multiple crossover trial conducted in a single individual to provide
evidence to directly inform personalized treatment decisions. Advancements in wearable …

Taken together, n-of-1 study design, wearable sensors and smartphone apps, and causal
analysis have the potential to revolutionize drug development and patient care. In this n-of-1 …

Background. Physical Activity (PA) plays a crucial role as a protective factor against many
diseases. Even though it is widely known that an appropriate level of PA contributes to …