Cytolethal distending toxin (CDT) is a heterotrimeric AB-type genotoxin produced by several
clinically important Gram-negative mucocutaneous bacterial pathogens. Irrespective of the …

Cytolethal distending toxin (CDT) is a bacterial toxin that initiates a eukaryotic cell cycle
block at the G2 stage prior to mitosis. CDT is produced by a number of bacterial pathogens …

▪ Abstract Periodontitis is mankind's most common chronic inflammatory disease. One
severe form of periodontitis is localized aggressive periodontitis (LAP), a condition to which …

Multiple pathogenic Gram‐negative bacteria produce cytolethal‐distending toxins (CDTs).
CDT is typically composed of three subunits: the catalytic subunit CdtB has DNase I‐like …

Bacterial cytolethal distending toxins (CDTs) containing DNase I‐like activity can induce
limited host DNA damage that leads to activation of the DNA‐damage repair responses in …

Since the 18th century a wealth of knowledge regarding infectious disease pathogenesis,
prevention, and treatment has been accumulated from findings of infection challenges in …

This review summarizes the current status and recent advances in our understanding of the
role that the cytolethal distending toxin (Cdt) plays as a virulence factor in promoting disease …

The recent report of the American Surgeon General on oral health in the USA [1] has shone
the spotlight on what is termed 'the silent epidemic of oral diseases–which …

Helicobacter hepaticus expresses a member of the cytolethal distending toxin (CDT) family
of bacterial cytotoxins. To investigate the role of CDT in the pathogenesis of H. hepaticus …

Transferable antibiotic resistance in Haemophilus influenzae was first detected in the early
1970s. After this, resistance spread rapidly worldwide and was shown to be transferred by a …