Emerging biosensing technologies for the diagnostics of viral infectious diseases

G Kabay, J DeCastro, A Altay, K Smith… - Advanced …, 2022 - Wiley Online Library
Several viral infectious diseases appear limitless since the beginning of the 21st century,
expanding into pandemic lengths. Thus, there are extensive efforts to provide more efficient …

Therapeutic cell engineering: designing programmable synthetic genetic circuits in mammalian cells

M Mansouri, M Fussenegger - Protein & Cell, 2022 - academic.oup.com
Cell therapy approaches that employ engineered mammalian cells for on-demand
production of therapeutic agents in the patient's body are moving beyond proof-of-concept in …

Synthetic Gene Circuits for Regulation of Next‐Generation Cell‐Based Therapeutics

AP Teixeira, M Fussenegger - Advanced Science, 2024 - Wiley Online Library
Arming human cells with synthetic gene circuits enables to expand their capacity to execute
superior sensing and response actions, offering tremendous potential for innovative cellular …

[PDF][PDF] SyNPL: Synthetic Notch pluripotent cell lines to monitor and manipulate cell interactions in vitro and in vivo

M Malaguti, R Portero Migueles, J Annoh… - …, 2022 - journals.biologists.com
Cell-cell interactions govern differentiation and cell competition in pluripotent cells during
early development, but the investigation of such processes is hindered by a lack of efficient …

Biomaterial-based immunoengineering to fight COVID-19 and infectious diseases

J Zarubova, X Zhang, T Hoffman… - Matter, 2021 - cell.com
Infection by SARS-CoV-2 virus often induces the dysregulation of immune responses, tissue
damage, and blood clotting. Engineered biomaterials from the nano-to the macroscale can …

An update on antiviral antibody-based biopharmaceuticals

S Ahangarzadeh, Z Payandeh, R Arezumand… - International …, 2020 - Elsevier
Due to the vastness of the science virology, it is no longer an offshoot solely of the
microbiology. Viruses have become as the causative agents of major epidemics throughout …

De novo-designed minibinders expand the synthetic biology sensing repertoire

ZY Weinberg, SS Soliman, MS Kim, DH Shah… - …, 2024 - pmc.ncbi.nlm.nih.gov
Synthetic and chimeric receptors capable of recognizing and responding to user-defined
antigens have enabled “smart” therapeutics based on engineered cells. These cell …

Cleavage of TANK-binding kinase 1 by HIV-1 protease triggers viral innate immune evasion

SS Jeremiah, K Miyakawa, S Matsunaga… - Frontiers in …, 2021 - frontiersin.org
Type-I interferons (IFN-I) are the innate immune system's principal defense against viral
infections. Human immunodeficiency virus-1 (HIV-1) has evolved several ways to suppress …

[HTML][HTML] Sentinel cells enable genetic detection of SARS-CoV-2 Spike protein

ZY Weinberg, CE Hilburger, M Kim, L Cao, M Khalid… - BioRxiv, 2021 - ncbi.nlm.nih.gov
The COVID-19 pandemic has demonstrated the need for exploring different diagnostic and
therapeutic modalities to tackle future viral threats. In this vein, we propose the idea of …

Establishment of monoclonal antibodies broadly neutralize infection of hepatitis B virus

H Zhang, Y Itoh, T Suzuki, K Ihara… - Microbiology and …, 2022 - Wiley Online Library
Antibodies against hepatitis B virus S protein can protect against hepatitis B virus (HBV)
infection. Therefore, hepatitis B immunoglobulin (HBIG), which contains HBsAb, is used …