Liquid chromatography (LC) is an incredibly successful analytical separation tool. Its
versatility is unprecedented because of the many different separation modes …

In this article we survey 256 references (with an emphasis on the papers published in the
past decade) on monolithic columns for intact protein separation. Protein enrichment and …

Multi-dimensional liquid chromatography techniques play an important role in the analysis of
complex mixtures. The keys to maximizing peak capacity in these methods are fast sampling …

A proof-of-concept study is presented on the use of comprehensive two-dimensional liquid
chromatography mass spectrometry (LC× LC-MS) for the separation of intact protein …

Proteome was first coined by describing the set of proteins encoded by the genome, and the
study of proteome, named as proteomics, aims at globally characterizing all components in a …

The development of novel high-resolution separation techniques is crucial for advancing the
complex sample analysis necessary for high-throughput top-down proteomics. Recently, our …

The separation in liquid chromatography is defined either by the space domain where it
proceeds until the least retained analyte reaches the outlet of the column or by the time …

Introduction Screening and analysis of bioactive components from natural products is a
fundamental part of new drug development and innovation. Two‐dimensional (2D) …

A simple yet efficient assay for the quantitation of proteins ranging from plasma proteins to
purified proteins from whole cell lysate, based on the bioconjugation reaction between …

Comprehensive elucidation of the composition of multiprotein complexes in model
organisms is essential to understand conserved biological systems, but large-scale mapping …