Polyglutamine diseases are a collection of nine CAG trinucleotide expansion disorders,
presenting with a spectrum of neurological and clinical phenotypes. Recent human, mouse …

The presence and aggregation of misfolded proteins has deleterious effects in the nervous
system. Among the various diseases caused by misfolded proteins is the family of the …

GGC repeat expansions within NOTCH2NLC have been identified as the genetic cause of
neuronal intranuclear inclusion disease (NIID). To understand the molecular pathogenesis …

Vesicular traffic and membrane contact sites between organelles enable the exchange of
proteins, lipids, and metabolites. Recruitment of tethers to contact sites between the …

Abstract Toll-like receptor (TLR) 4 contributes to be the induction of neuroinflammation by
recognizing pathology-associated ligands and activating microglia. In addition, numerous …

Rotenone remains an efficient pesticide used extensively in agriculture, leading to
neurotoxicity and the increase of the prevalence of Parkinson's disease (PD). Previous …

Polyglutamine spinocerebellar ataxias (polyQ SCAs) include SCA1, SCA2, SCA3, SCA6,
SCA7, and SCA17 and constitute a group of adult onset neurodegenerative disorders …

Spinocerebellar ataxias (SCAs) are a heterogeneous group of autosomal dominantly
inherited progressive disorders with degeneration and dysfunction of the cerebellum …

Abstract Spinocerebellar ataxia type 17 (SCA17) is a neurodegenerative disease caused by
a polyglutamine-encoding trinucleotide repeat expansion in the gene of transcription factor …

Lysosomes serve as dynamic regulators of cell and organismal physiology by integrating the
degradation of macromolecules with receptor and nutrient signaling. Previous studies have …