Pancreatic β-cell electrical activity and insulin secretion: of mice and men
P Rorsman, FM Ashcroft - Physiological reviews, 2018 - journals.physiology.org
The pancreatic β-cell plays a key role in glucose homeostasis by secreting insulin, the only
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …
hormone capable of lowering the blood glucose concentration. Impaired insulin secretion …
Regulation of insulin secretion in human pancreatic islets
P Rorsman, M Braun - Annual review of physiology, 2013 - annualreviews.org
Pancreatic β cells secrete insulin, the body's only hormone capable of lowering plasma
glucose levels. Impaired or insufficient insulin secretion results in diabetes mellitus. The β …
glucose levels. Impaired or insufficient insulin secretion results in diabetes mellitus. The β …
Voltage-gated potassium channels as therapeutic targets
The human genome encodes 40 voltage-gated K+ channels (KV), which are involved in
diverse physiological processes ranging from repolarization of neuronal and cardiac action …
diverse physiological processes ranging from repolarization of neuronal and cardiac action …
Leptin modulates the intrinsic excitability of AgRP/NPY neurons in the arcuate nucleus of the hypothalamus
SB Baver, K Hope, S Guyot, C Bjørbaek… - Journal of …, 2014 - Soc Neuroscience
The hypothalamic arcuate nucleus (ARH) is a brain region critical for regulation of food
intake and a primary area for the action of leptin in the CNS. In lean mice, the adipokine …
intake and a primary area for the action of leptin in the CNS. In lean mice, the adipokine …
Identification of VAPA and VAPB as Kv2 channel-interacting proteins defining endoplasmic reticulum–plasma membrane junctions in mammalian brain neurons
M Kirmiz, NC Vierra, S Palacio… - Journal of …, 2018 - Soc Neuroscience
Membrane contacts between endoplasmic reticulum (ER) and plasma membrane (PM), or
ER-PM junctions, are ubiquitous in eukaryotic cells and are platforms for lipid and calcium …
ER-PM junctions, are ubiquitous in eukaryotic cells and are platforms for lipid and calcium …
The triggering pathway to insulin secretion: Functional similarities and differences between the human and the mouse β cells and their translational relevance
In β cells, stimulation by metabolic, hormonal, neuronal, and pharmacological factors is
coupled to secretion of insulin through different intracellular signaling pathways. Our …
coupled to secretion of insulin through different intracellular signaling pathways. Our …
In vitro and in vivo antidiabetic potential of monoterpenoids: An update
Diabetes mellitus (DM) is a chronic metabolic condition characterized by persistent
hyperglycemia due to insufficient insulin levels or insulin resistance. Despite the availability …
hyperglycemia due to insufficient insulin levels or insulin resistance. Despite the availability …
In silico prediction of novel therapeutic targets using gene–disease association data
Background Target identification and validation is a pressing challenge in the
pharmaceutical industry, with many of the programmes that fail for efficacy reasons showing …
pharmaceutical industry, with many of the programmes that fail for efficacy reasons showing …
Electrophysiology of islet cells
G Drews, P Krippeit-Drews, M Düfer - The islets of langerhans, 2010 - Springer
Abstract Stimulus-Secretion Coupling (SSC) of pancreatic islet cells comprises electrical
activity. Changes of the membrane potential (V m) are regulated by metabolism-dependent …
activity. Changes of the membrane potential (V m) are regulated by metabolism-dependent …
Photoswitchable diacylglycerols enable optical control of protein kinase C
Increased levels of the second messenger lipid diacylglycerol (DAG) induce downstream
signaling events including the translocation of C1-domain-containing proteins toward the …
signaling events including the translocation of C1-domain-containing proteins toward the …