Long-read sequencing technologies have now reached a level of accuracy and yield that
allows their application to variant detection at a scale of tens to thousands of samples …

Proteins are responsible for the occurrence and treatment of many diseases, and therefore
protein sequencing will revolutionize proteomics and clinical diagnostics. Biological …

Direct protein sequencing technologies with improved sensitivity and throughput are still
needed. Here, we propose an alternative method for peptide sequencing based on …

Biotechnological innovations have vastly improved the capacity to perform large-scale
protein studies, while the methods we have for identifying and quantifying individual proteins …

The chemical nature and precise position of posttranslational modifications (PTMs) in
proteins or peptides are crucial for various severe diseases, such as cancer. State-of-the-art …

Nanopore platform holds a great fascination that attracts increasing interests in research and
leads the development of various domains. Herein we first briefly introduce the …

Sequence identification of peptides and proteins is central to proteomics. Protein
sequencing is mainly conducted by insensitive mass spectroscopy because proteins cannot …

In two decades, the solid state and polymer nanopores became attractive method for the
protein sensing with high specificity and sensitivity. They also allow the characterization of …

Biological nanopores are emerging as sensitive single-molecule sensors for proteins and
peptides. The heterogeneous charge of a polypeptide chain, however, can complicate or …

Tailored transmembrane alpha-helical pores with desired structural and functional versatility
have promising applications in nanobiotechnology. Herein, we present a transmembrane …