Compelling evidence for the inherited nature of essential hypertension has led to extensive
research in rats and humans. Rats have served as the primary model for research on the …

Hypertension is still one of the major causes of death from cardiovascular failure. Increased
salt intake may aggravate the rise in blood pressure and the development of consequential …

We used N-ethyl-N-nitrosurea–induced germline mutagenesis combined with automated
meiotic mapping to identify specific systolic blood pressure (SBP) and heart rate (HR) …

Abstract Purpose of the Review Blood pressure regulation in humans has long been known
to be a genetically determined trait. The identification of causal genetic modulators for this …

Hypertension is a complex trait that has been studied extensively for genetic contributions of
the nuclear genome. We examined mitochondrial genomes of the hypertensive strains: the …

Rat models have been used to investigate physiological and pathophysiological
mechanisms for decades. With the availability of the rat genome and other online resources …

Genetic influences contribute upto 30–50% to blood pressure variability in human essential
hypertension [1]. Intense efforts have been dedicated to unraveling the role of genes in this …

Through linkage analysis of the Dahl salt-sensitive (S) rat and the spontaneously
hypertensive rat (SHR), a blood pressure (BP) quantitative trait locus (QTL) was previously …

Individuals with cardiovascular and metabolic diseases (CVD) are shown to be more
susceptible to adverse health effects of pollutants. Rodent models of CVD are used for …

Metabolic syndrome is a highly prevalent human disease with substantial genomic and
environmental components. Previous studies indicate the presence of significant genetic …