As the main protein components of chromatin, histones play central roles in gene regulation
as spools of winding DNA. Histones are subject to various modifications, including …

Abstract Peptidylarginine deiminase (PAD, EC 3.5. 3.15) enzymes catalyze the conversion
of protein‐bound arginine to citrulline. This post‐translational modification may have a big …

Epigenetic marking systems confer stability of gene expression during mammalian
development. Genome-wide epigenetic reprogramming occurs at stages when …

Post-translational modifications (PTMs) of histone proteins are a hallmark of epigenetic
regulation. They provide a mechanism to modulate chromatin structure and constitute the …

Peptidylarginine deiminases are a family of enzymes that mediate post-translational
modifications of protein arginine residues by deimination or demethylimination to produce …

The global COVID-19 pandemic has the potential to severely affect those with rheumatic
diseases or who are taking immunosuppressive therapies. Information is lacking as to how …

Peptidylarginine deiminases (PADs) have an important role in the pathogenesis of
rheumatoid arthritis (RA) owing to their ability to generate citrullinated proteins—the …

Early embryonic arrest is one of the major causes of female infertility. However, because of
difficulties in phenotypic evaluation, genetic determinants of human early embryonic arrest …

Objective Autoantibodies to citrullinated proteins (ACPAs) are specific for rheumatoid
arthritis (RA) and probably are involved in its pathophysiology. Citrullyl residues …

Rheumatoid arthritis is associated with the development of autoantibodies to citrullinated
self-proteins. Citrullinated synovial proteins, which are generated via the actions of the …