Emergence of SARS-CoV-2 through recombination and strong purifying selection
COVID-19 has become a global pandemic caused by the novel coronavirus SARS-CoV-2.
Understanding the origins of SARS-CoV-2 is critical for deterring future zoonosis …
Understanding the origins of SARS-CoV-2 is critical for deterring future zoonosis …
Spin-enhanced nanodiamond biosensing for ultrasensitive diagnostics
The quantum spin properties of nitrogen-vacancy defects in diamond enable diverse
applications in quantum computing and communications. However, fluorescent …
applications in quantum computing and communications. However, fluorescent …
Learning the language of viral evolution and escape
The ability for viruses to mutate and evade the human immune system and cause infection,
called viral escape, remains an obstacle to antiviral and vaccine development …
called viral escape, remains an obstacle to antiviral and vaccine development …
The COVID misinfodemic: not new, never more lethal
C Apetrei, PA Marx, JW Mellors, I Pandrea - Trends in Microbiology, 2022 - cell.com
'Infodemia'is a portmanteau between 'information'and 'epidemics', referring to wide and rapid
accumulation and dissemination of information, misinformation, and disinformation about a …
accumulation and dissemination of information, misinformation, and disinformation about a …
Virus Variation Resource–improved response to emergent viral outbreaks
EL Hatcher, SA Zhdanov, Y Bao, O Blinkova… - Nucleic acids …, 2017 - academic.oup.com
Abstract The Virus Variation Resource is a value-added viral sequence data resource
hosted by the National Center for Biotechnology Information. The resource is located at …
hosted by the National Center for Biotechnology Information. The resource is located at …
Human neutralizing antibodies to cold linear epitopes and subdomain 1 of the SARS-CoV-2 spike glycoprotein
Emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants
diminishes the efficacy of vaccines and antiviral monoclonal antibodies. Continued …
diminishes the efficacy of vaccines and antiviral monoclonal antibodies. Continued …
Population genomics of intrapatient HIV-1 evolution
F Zanini, J Brodin, L Thebo, C Lanz, G Bratt, J Albert… - Elife, 2015 - elifesciences.org
Many microbial populations rapidly adapt to changing environments with multiple variants
competing for survival. To quantify such complex evolutionary dynamics in vivo, time …
competing for survival. To quantify such complex evolutionary dynamics in vivo, time …
Face-time with TAR: Portraits of an HIV-1 RNA with diverse modes of effector recognition relevant for drug discovery
Small molecules and short peptides that potently and selectively bind RNA are rare, making
the molecular structures of these complexes highly exceptional. Accordingly, several recent …
the molecular structures of these complexes highly exceptional. Accordingly, several recent …
Antibody lineages with vaccine-induced antigen-binding hotspots develop broad HIV neutralization
The vaccine-mediated elicitation of antibodies (Abs) capable of neutralizing diverse HIV-1
strains has been a long-standing goal. To understand how broadly neutralizing antibodies …
strains has been a long-standing goal. To understand how broadly neutralizing antibodies …
CRISPR/Cas9 system targeting regulatory genes of HIV-1 inhibits viral replication in infected T-cell cultures
The CRISPR/Cas9 system provides a novel and promising tool for editing the HIV-1 proviral
genome. We designed RNA-guided CRISPR/Cas9 targeting the HIV-1 regulatory genes tat …
genome. We designed RNA-guided CRISPR/Cas9 targeting the HIV-1 regulatory genes tat …