All solid tumours require a vascular supply in order to progress. Although the ability to
induce angiogenesis (new blood vessel growth) has long been regarded as essential to this …

The hallmarks of cancer comprise six biological capabilities acquired during the multistep
development of human tumors. The hallmarks constitute an organizing principle for …

We conducted a first-in-human study of intravenous delivery of a single dose of autologous T
cells redirected to the epidermal growth factor receptor variant III (EGFRvIII) mutation by a …

PURPOSE: NovoTTF-100A is a portable device delivering low-intensity, intermediate
frequency electric fields via non-invasive, transducer arrays. Tumour Treatment Fields (TTF) …

In theory, in vitro and in vivo models for human gliomas have great potential to not only
enhance our understanding of glioma biology, but also to facilitate the development of novel …

Glioblastoma is the most common and most aggressive primary brain tumour. Standard of
care consists of surgical resection followed by radiotherapy and concomitant and …

Glioblastoma is both the most common and lethal primary malignant brain tumor. Extensive
multiplatform genomic characterization has provided a higher-resolution picture of the …

Targeted therapies and the consequent adoption of “personalized” oncology have achieved
notable successes in some cancers; however, significant problems remain with this …

Chimeric antigen receptors (CARs) are synthetic molecules designed to redirect T cells to
specific antigens. CAR-modified T cells can mediate long-term durable remissions in B cell …

Cancer stem cells (CSCs) have emerged as key contributors to tumor initiation, growth, and
metastasis. In addition, CSCs play a significant role in inducing immune evasion, thereby …