Natural products have played significant roles as medicine and food throughout human
history. Here, we first provide a brief historical overview of natural products, their …

We report on the latest advancements in Microcrystal Electron Diffraction (3D ED/MicroED),
as discussed during a symposium at the National Center for CryoEM Access and Training …

Discovery of cancer immunogenic chemotherapeutics represents an emerging, highly
promising direction for cancer treatment that uses a chemical drug to achieve the efficacy of …

Along with the adoption of three-dimensional electron diffraction (3D ED/MicroED) as a
mainstream tool for structure determination from sub-micron single crystals, questions about …

Natural products biosynthesized from biocontrol fungi in the rhizosphere can have both
beneficial and deleterious effects on plants. Herein, we performed a comprehensive …

Microbial secondary metabolites not only have key roles in microbial processes and
relationships but are also valued in various sectors of today's economy, especially in human …

Direct electron detectors are now a mainstay in cryoEM, and are increasingly used for
electron diffraction measurements. Event-based electron counting (EBEC), in particular …

Small molecule metabolites drive inter-and intraspecies communication and dependencies
in diverse biological systems, yet a large proportion of these important chemical compounds …

Nature remains a vast repository of complex and functional metabolites whose structural
characterization continues to drive innovations in pharmaceuticals, agrochemicals, and …