Small molecule NF-κB pathway inhibitors in clinic

V Ramadass, T Vaiyapuri, V Tergaonkar - International journal of …, 2020 - mdpi.com
Nuclear factor kappa B (NF-κB) signaling is implicated in all major human chronic diseases,
with its role in transcription of hundreds of gene well established in the literature. This has …

Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications

Q Zhong, X Xiao, Y Qiu, Z Xu, C Chen, B Chong… - MedComm, 2023 - Wiley Online Library
Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Subcellular proteomics

JA Christopher, C Stadler, CE Martin… - Nature Reviews …, 2021 - nature.com
The eukaryotic cell is compartmentalized into subcellular niches, including membrane-
bound and membrane-less organelles. Proteins localize to these niches to fulfil their …

ATR-FTIR spectroscopy and spectroscopic imaging for the analysis of biopharmaceuticals

H Tiernan, B Byrne, SG Kazarian - … Acta Part A: Molecular and Biomolecular …, 2020 - Elsevier
Abstract Attenuated Total Reflection Fourier Transform Infrared (ATR-FTIR) spectroscopy is
a label-free, non-destructive technique that can be applied to a vast range of biological …

Post-translational modification prediction via prompt-based fine-tuning of a GPT-2 model

P Shrestha, J Kandel, H Tayara, KT Chong - Nature Communications, 2024 - nature.com
Post-translational modifications (PTMs) are pivotal in modulating protein functions and
influencing cellular processes like signaling, localization, and degradation. The complexity …

Applications of capillary electromigration methods for separation and analysis of proteins (2017–mid 2021)–a review

S Štěpánová, V Kašička - Analytica Chimica Acta, 2022 - Elsevier
This paper provides a detailed overview of relevant developments in separation and
analysis of proteins by capillary electromigration (CE) methods in the period 2017–mid …

Advances in enrichment methods for mass spectrometry-based proteomics analysis of post-translational modifications

J Brandi, R Noberini, T Bonaldi, D Cecconi - Journal of Chromatography A, 2022 - Elsevier
Post-translational modifications (PTMs) occur during or after protein biosynthesis and
increase the functional diversity of proteome. They comprise phosphorylation, acetylation …

Post-translational control of RNA-binding proteins and disease-related dysregulation

A Velázquez-Cruz, B Baños-Jaime… - Frontiers in molecular …, 2021 - frontiersin.org
Cell signaling mechanisms modulate gene expression in response to internal and external
stimuli. Cellular adaptation requires a precise and coordinated regulation of the transcription …

Characterizing endogenous protein complexes with biological mass spectrometry

R Rogawski, M Sharon - Chemical reviews, 2021 - ACS Publications
Biological mass spectrometry (MS) encompasses a range of methods for characterizing
proteins and other biomolecules. MS is uniquely powerful for the structural analysis of …

Post‐translational regulation of muscle growth, muscle aging and sarcopenia

Q Zhong, K Zheng, W Li, K An, Y Liu… - Journal of Cachexia …, 2023 - Wiley Online Library
Abstract Skeletal muscle makes up 30–40% of the total body mass. It is of great significance
in maintaining digestion, inhaling and exhaling, sustaining body posture, exercising …