This article reviews and summarizes 200 years of Parkinson's disease. It comprises a
relevant history of Dr. James Parkinson's himself and what he described accurately and …

Non motor symptoms (NMS) represent a significant burden in Parkinson's disease (PD) with
numerous studies highlighting the importance of NMS both in “pre-motor” phase of PD as …

Importance There is increasing evidence that Parkinson disease (PD) is heterogeneous in
its clinical presentation and prognosis. Defining subtypes of PD is needed to better …

Nonmotor symptoms (NMS) in Parkinson's disease (PD) can precede onset of motor
symptoms. Relationship between premotor symptoms onset and motor features is limited …

Although commonly observed in clinical practice, the heterogeneity of obstructive sleep
apnoea (OSA) clinical presentation has not been formally characterised. This study was the …

We conducted a systematic review and meta‐analysis aimed at establishing robust
prevalence estimates and identifying clinical correlates of fatigue in PD. From 2,459 titles …

Parkinson's disease is highly heterogeneous in early clinical features and later outcomes.
This makes classifying subgroups of PD relevant to clinical research and practice …

Emerging concepts suggest that a multitude of pathology ranging from misfolding of alpha-
synuclein to neuroinflammation, mitochondrial dysfunction, and neurotransmitter driven …

This study was undertaken to determine the prevalence and correlates of cognitive
impairment (CI) and neuropsychiatric symptoms (NPS) in early, untreated patients with …

Background Mitochondrial dysfunction and defects in oxidative metabolism are a
characteristic feature of many chronic illnesses not currently classified as mitochondrial …