[HTML][HTML] Phase separation and neurodegenerative diseases: a disturbance in the force

A Zbinden, M Pérez-Berlanga, P De Rossi… - Developmental cell, 2020 - cell.com
Protein aggregation is the main hallmark of neurodegenerative diseases. Many proteins
found in pathological inclusions are known to undergo liquid-liquid phase separation, a …

Opportunities for histone deacetylase inhibition in amyotrophic lateral sclerosis

YE Klingl, D Pakravan… - British Journal of …, 2021 - Wiley Online Library
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease. ALS
patients suffer from a progressive loss of motor neurons, leading to respiratory failure within …

Hsp70 chaperones TDP-43 in dynamic, liquid-like phase and prevents it from amyloid aggregation

J Gu, C Wang, R Hu, Y Li, S Zhang, Y Sun, Q Wang… - Cell Research, 2021 - nature.com
Dear Editor, TAR DNA-binding protein 43 kDa (TDP-43) undergoes liquid–liquid phase
separation (LLPS) and forms reversible, cytoprotective nuclear bodies (NBs) under stress. 1 …

Visualizing molecular architectures of cellular condensates: hints of complex coacervation scenarios

SK Goetz, J Mahamid - Developmental Cell, 2020 - cell.com
In the last decade, liquid-liquid phase separation has emerged as a fundamental principle in
the organization of crowded cellular environments into functionally distinct membraneless …

Zn2+ modulates in vitro phase separation of TDP-432C and mutant TDP-432C-A315T C-terminal fragments of TDP-43 protein implicated in ALS and FTLD-TDP …

S Preethi, V Bharathi, BK Patel - International journal of biological …, 2021 - Elsevier
TDP-43 proteinopathy is implicated in the neurodegenerative diseases, ALS and FTLD-TDP.
Metal ion dyshomeostasis is observed in neurodegenerative diseases including ALS …