Next-generation sequencing (NGS) is rapidly expanding into routine oncology practice.
Genetic variations in both the cancer and inherited genomes are informative for hereditary …

Abstract Comprehensive Genomic Profiling (CGP) allows for the identification of many
targets. Reimbursement decision-making is, however, challenging because besides the …

In the era of precision medicine, genomic interrogation for identification of both germline and
somatic genetic alterations has become increasingly important. While such germline testing …

A germline pathogenic variant may be present even if the results of tumor genomic
sequencing do not suggest one. There are key differences in the assay design and reporting …

Next-generation sequencing of circulating tumor DNA (ctDNA) is a non-invasive method to
guide therapy selection for cancer patients. ctDNA variant allele frequency (VAF) is …

PURPOSE Tumor next-generation sequencing (NGS) testing identifies possible germline
pathogenic variants (PGPVs), creating a dilemma for appropriate recognition, triage, and …

Simple Summary Colorectal cancer is often associated with MUTYH mutations, but their
connection to breast cancer remains unclear. We aimed to assess if MUTYH mutations …

Objectives Lynch syndrome increases risks for colorectal and other cancers. Though
published Lynch syndrome cancer risk-management guidelines are effective for risk …

Introduction High-throughput sequencing techniques have revolutionized oncology. Paired
germline-tumor DNA analysis has emerged as a comprehensive strategy to uncover …

Multiple primary tumors (MPTs) are a harbinger of hereditary cancer syndromes. Affected
individuals often fit genetic testing criteria for a number of hereditary cancer genes and …