Enzymes that catalyze the biotransformation of drugs and xenobiotics are generally referred
to as drug‐metabolizing e nzymes (DMEs). DMEs can be classified into two main groups …

The reactivity of the cobalt-carbon bond in cobalamins is the key to their chemical versatility,
supporting both methyl transfer and isomerization reactions. During evolution of higher …

During the fifteen years since the bestselling first edition of Folate in Health and Disease
was published, there have been thousands of new research studies related to folate and its …

The mystery of how the cyanide group in vitamin B12 or cyanocobalamin, discovered 60
years ago, is removed, has been solved by the demonstration that the trafficking chaperone …

A comprehensive review on redox reactions of Co (III), Co (II) and Co (I) forms of cobalamins
(vitamin B12) and their derivatives (cobinamide, cobyrinates) is presented. An influence of …

Background Abnormalities of folate and homocysteine metabolism are associated with a
number of pediatric and adult disorders. Folate intake and genetic polymorphisms encoding …

Conspectus Metals are partners for an estimated one-third of the proteome and vary in
complexity from mononuclear centers to organometallic cofactors. Vitamin B12 or cobalamin …

Many coenzymes are vitamins that are assimilated in mammals into their active form from
precursors obtained from the diet. They are often both rare and reactive rendering the …

Neural-tube defects (NTD) are common congenital malformations that can lead to severe
disability or even death. Periconceptional supplementation with the B-vitamin folic acid has …

Epidemiological studies have evaluated the association between maternal
methylenetetrahydrofolate reductase (MTHFR) C677T, A1298C and methionine synthase …