It is now becoming apparent that dynamic changes occur within the interstitium that directly
contribute to adverse myocardial remodeling following myocardial infarction (MI), with …

When migrating away from a primary tumour, cancer cells interact with and remodel the
extracellular matrix (ECM). Matrix metalloproteinases (MMPs), and in particular the …

Energy use, mainly to reverse ion movements in neurons, is a fundamental constraint on
brain information processing. Trafficking of mitochondria to locations in neurons where there …

Adaption of a single protein to perform multiple independent functions facilitates functional
plasticity of the proteome allowing a limited number of protein-coding genes to perform a …

Matrix metalloproteinases (MMPs), originally discovered to function in the breakdown of
extracellular matrix proteins, have gained the status of regulatory proteases in signaling …

Cells release multiple, distinct forms of extracellular vesicles including structures known as
microvesicles, which are known to alter the extracellular environment. Despite growing …

Matrix metalloproteinases (MMPs) have been shown to be key players in both extracellular
matrix remodeling and cell migration during cancer metastasis. MMP-14, a membrane …

ABSTRACT Three-dimensional (3D) cell motility underlies essential processes, such as
embryonic development, tissue repair and immune surveillance, and is involved in cancer …

Membrane type-1 matrix metalloproteinase (MT1-MMP) is a promising drug target in
malignancy. The structure of MT1-MMP includes the hemopexin domain (PEX) that is distinct …

The matrix metalloproteinase (MMP) MT1-MMP plays pivotal roles in leukocyte physiology
such as monocyte diapedesis, dendritic cell migration, and T-cell homing. MT1-MMP is a …