Applications of focused ultrasound in the brain: from thermoablation to drug delivery

Y Meng, K Hynynen, N Lipsman - Nature Reviews Neurology, 2021 - nature.com
Focused ultrasound (FUS) is a disruptive medical technology, and its implementation in the
clinic represents the culmination of decades of research. Lying at the convergence of …

Opportunities and challenges in delivering biologics for Alzheimer's disease by low-intensity ultrasound

L Chen, E Cruz, LE Oikari, P Padmanabhan… - Advanced Drug Delivery …, 2022 - Elsevier
Low-intensity ultrasound combined with intravenously injected microbubbles (US+ MB) is a
novel treatment modality for brain disorders, including Alzheimer's disease (AD), safely and …

Selective ablation of cancer cells with low intensity pulsed ultrasound

DR Mittelstein, J Ye, EF Schibber… - Applied Physics …, 2020 - pubs.aip.org
Ultrasound can be focused into deep tissues with millimeter precision to perform
noninvasive ablative therapy for diseases such as cancer. In most cases, this ablation uses …

High-intensity focused ultrasound ablation for unresectable primary and metastatic liver cancer: real-world research in a Chinese tertiary center with 275 cases

Y Ji, J Zhu, L Zhu, Y Zhu, H Zhao - Frontiers in oncology, 2020 - frontiersin.org
This retrospective analysis was conducted to evaluate the feasibility and safety of high-
intensity focused ultrasound ablation for primary liver cancer and metastatic liver cancer …

Proton resonance frequency shift thermometry: a review of modern clinical practices

J Blackwell, MJ Kraśny, A O'Brien… - Journal of Magnetic …, 2022 - Wiley Online Library
Magnetic resonance imaging (MRI) has become a popular modality in guiding minimally
invasive thermal therapies, due to its advanced, nonionizing, imaging capabilities and its …

Boiling histotripsy-induced partial mechanical ablation modulates tumour microenvironment by promoting immunogenic cell death of cancers

KJ Pahk, CH Shin, IY Bae, Y Yang, SH Kim, K Pahk… - Scientific reports, 2019 - nature.com
Boiling histotripsy is a promising non-invasive High-Intensity Focused Ultrasound (HIFU)
technique that employs HIFU mechanical effects to fractionate solid tumours without causing …

Design of HIFU transducers for generating specified nonlinear ultrasound fields

PB Rosnitskiy, PV Yuldashev… - IEEE transactions on …, 2016 - ieeexplore.ieee.org
Various clinical applications of high-intensity focused ultrasound have different requirements
for the pressure levels and degree of nonlinear waveform distortion at the focus. The goal of …

Mechanotherapy in oncology: Targeting nuclear mechanics and mechanotransduction

S Liu, Y Li, Y Hong, M Wang, H Zhang, J Ma… - Advanced Drug Delivery …, 2023 - Elsevier
Mechanotherapy is proposed as a new option for cancer treatment. Increasing evidence
suggests that characteristic differences are present in the nuclear mechanics and …

[HTML][HTML] Systematic review of the role of high intensity focused ultrasound (HIFU) in treating malignant lesions of the hepatobiliary system

AS Sehmbi, S Froghi, MO de Andrade, N Saffari… - HPB, 2021 - Elsevier
Abstract Background High Intensity Focused Ultrasound (HIFU) is an emerging non-
invasive, targeted treatment of malignancy. The aim of this review was to assess the efficacy …

Review of robot-assisted HIFU therapy

A Gunderman, R Montayre, A Ranjan, Y Chen - Sensors, 2023 - mdpi.com
This paper provides an overview of current robot-assisted high-intensity focused ultrasound
(HIFU) systems for image-guided therapies. HIFU is a minimally invasive technique that …