Apoptosis of cells and their subsequent removal through efferocytosis occurs in nearly all
tissues during development, homeostasis, and disease. However, it has been difficult to …

Protein depletion by genetic means, in a very general sense including the use of RNA
interference [1, 2] or CRISPR/Cas9-based methods, represents a central paradigm of …

Mitotic cells assume a spherical shape by increasing their surface tension and osmotic
pressure by extensively reorganizing their interphase actin cytoskeleton into a cortical …

Recent studies suggest that the activity of epithelial sodium channels (ENaC) is increased
by phosphatidylinositides, especially phosphatidylinositol 4, 5-bisphosphate (PI (4, 5) P 2) …

The dynamics of extracellular signal-regulated kinase (ERK) signaling underlies its versatile
functions in cell differentiation, cell proliferation, and cell motility. Classical studies in …

Exposure to stress increases the risk of developing affective disorders such as depression
and post-traumatic stress disorder (PTSD). However, these disorders occur in only a subset …

The mechanisms by which synaptic partners recognize each other and establish appropriate
numbers of connections during embryonic development to form functional neural circuits are …

The vertebrate tight junction is a critical claudin-based cell–cell junction that functions to
prevent free paracellular diffusion between epithelial cells. In Drosophila, this barrier is …

The nonsense-mediated mRNA decay (NMD) pathway functions to degrade both abnormal
and wild-type mRNAs. NMD is essential for viability in most organisms, but the molecular …

The analysis of consequences resulting after experimental elimination of gene function has
been and will continue to be an extremely successful strategy in biological research …