Cobalt ferrite nanoparticles (CFN) have drawn attention as a theranostic agent. Unique
physicochemical features of CFN and magnetic properties make CFN an outstanding …

The conventional battery for genotoxicity testing is not well suited to assessing the large
number of chemicals needing evaluation. Traditional in vitro tests lack throughput, provide …

Diclofenac is a non-steroidal anti-inflammatory drug discovered several decades ago, which
has since been used by an estimated one billion patients and has demonstrated an …

Genetic mutation of the leucine-rich repeat kinase 2 (LRRK2) protein has been associated
with Parkinson's disease (PD), a disabling and progressive neurodegenerative disorder that …

In vitro (geno) toxicity assessment of electronic vapour products (EVPs), relative to
conventional cigarette, currently uses assays, including the micronucleus and Ames tests …

We have previously described two flow cytometry-based in vitro genotoxicity tests:
micronucleus (MN) scoring (MicroFlow®) and a multiplexed DNA damage response …

The NRF2-KEAP1 interaction is central for cytoprotection against stresses, giving it high
clinical significance. Covalent modification of KEAP1 is an efficient approach, but the …

Background An enhanced aerobic glycolysis (“Warburg effect”) associated with an increase
in lactic acid in the tumor microenvironment contributes to tumor aggressiveness and …

A key step in the risk assessment process of a substance is the assessment of its genotoxic
potential. Irrespective of the industry involved, current approaches rely on combinations of …

The regulatory 2D in vitro micronucleus (MN) assay is part of a battery of tests, used to test
for genotoxicity of new and existing compounds before they are assessed in vivo (ICH S2) …