Abstract Neohesperidin (hesperetin 7-O-neohesperidoside), a well-known flavanone
glycoside widely found in citrus fruits, exhibits a variety of biological activities, with potential …

Anthraquinones constitute an important class of natural and synthetic compounds with a
broad scope of pharmacological including anti-bacterial, antioxidant, laxative, anti-tumor …

Protein misfolding diseases (PMDs) are chronic and progressive, with no effective therapy
so far. Aggregation and misfolding of amyloidogenic proteins are closely associated with the …

We found that hesperidin, a plant-derived bioflavonoid, may be a candidate agent for
neuroprotective treatment in the retina, after screening 41 materials for anti-oxidative …

The anti-aging activity of many plant flavonoids, as well as their mechanisms of action, have
been explored in the current literature. However, the studies on the synergistic effects …

Neuronal mitochondrial oxidative stress induced by β-amyloid (Aβ) is an early event of
Alzheimer's disease (AD). Emerging evidence has shown that antioxidant therapy …

Background Neuropathic pain is a multifaceted and ubiquitous disease across the globe.
Mood disorders, such as anxiety and depression, are frequently observed in patients …

Danggui-Shaoyao-San (DSS), also called Toki-shakuyaku-san (TJ-23) or Dangguijakyak-
san (DJS), is a well-known herbal formula (Angelica sinensis (Oliv.) Diels., Ligusticum …

Among the various neurodegenerative disorders, Alzheimer's disease (AD) is identified as
one of primary causes of dementia in the elderly, which progresses slowly leading to …

Depression is a primary public health problem. However, current antidepressants work
slowly, and together with side effects. Herein, the alginate nanogels were constructed to …