3-3 proteins are highly conserved regulatory proteins that interact with hundreds of
structurally diverse clients and act as central hubs of signaling networks. However, how 14-3 …

Proteotoxic stress causes profound endoplasmic reticulum (ER) membrane remodeling into
a perinuclear quality control compartment (ERQC) for the degradation of misfolded proteins …

Toxic protein aggregates can spread among neurons to promote human neurodegenerative
disease pathology. We found that in C. elegans touch neurons intermediate filament …

Astronauts on board the International Space Station (ISS) are exposed to the damaging
effects of microgravity and cosmic radiation. One of the most critical and sensitive districts of …

The Golgi complex comprises a connected ribbon of stacked cisternal membranes localized
to the perinuclear region in most vertebrate cells. The position and morphology of this …

Mycoplasma pneumoniae is the most common pathogen causing respiratory tract infection,
and the P1 protein on its adhesion organelle plays a crucial role during the pathogenic …

Organochlorine pesticides constitute the majority of the total environmental pollutants, and a
wide range of compounds have been found to be carcinogenic to humans. Among all …

A novel hybrid nanocomposite formed of carboxylated Nano Graphene Oxide (c-NGO),
highly densely decorated by monodisperse citrate-coated Au nanoparticles (c-NGO/Au …

We introduced enhanced UnaG (eUnaG), a ligand-activatable fluorescent protein, for
conventional and super-resolution imaging of subcellular structures in the mammalian cells …

Calcium (Ca2+) is the third most abundant metal on earth, and the fundaments of its
homeostasis date back to pre-eukaryotic life forms. In higher organisms, Ca2+ serves as a …