Antibiotic perturbations to the gut microbiome

SRS Fishbein, B Mahmud, G Dantas - Nature Reviews Microbiology, 2023 - nature.com
Antibiotic-mediated perturbation of the gut microbiome is associated with numerous
infectious and autoimmune diseases of the gastrointestinal tract. Yet, as the gut microbiome …

Next-generation sequencing: insights to advance clinical investigations of the microbiome

CR Wensel, JL Pluznick, SL Salzberg… - The Journal of clinical …, 2022 - Am Soc Clin Investig
Next-generation sequencing (NGS) technology has advanced our understanding of the
human microbiome by allowing for the discovery and characterization of unculturable …

A systematic review of gut microbiota composition in observational studies of major depressive disorder, bipolar disorder and schizophrenia

AJ McGuinness, JA Davis, SL Dawson… - Molecular …, 2022 - nature.com
The emerging understanding of gut microbiota as 'metabolic machinery'influencing many
aspects of physiology has gained substantial attention in the field of psychiatry. This is …

Metagenomics of Parkinson's disease implicates the gut microbiome in multiple disease mechanisms

ZD Wallen, A Demirkan, G Twa, G Cohen… - Nature …, 2022 - nature.com
Parkinson's disease (PD) may start in the gut and spread to the brain. To investigate the role
of gut microbiome, we conducted a large-scale study, at high taxonomic resolution, using …

Human microbiome myths and misconceptions

AW Walker, L Hoyles - Nature microbiology, 2023 - nature.com
Over the past two decades, interest in human microbiome research has increased
exponentially. Regrettably, this increased activity has brought with it a degree of hype and …

The gut microbiome and hypertension

JA O'Donnell, T Zheng, G Meric… - Nature Reviews …, 2023 - nature.com
A large body of evidence has emerged in the past decade supporting a role for the gut
microbiome in the regulation of blood pressure. The field has moved from association to …

Challenges and opportunities in sharing microbiome data and analyses

C Huttenhower, RD Finn, AC McHardy - Nature Microbiology, 2023 - nature.com
Microbiome data, metadata and analytical workflows have become 'big'in terms of volume
and complexity. Although the infrastructure and technologies to share data have been …

Gut microbiota and their metabolites in stroke: a double-edged sword

A Peh, JA O'Donnell, BRS Broughton, FZ Marques - Stroke, 2022 - Am Heart Assoc
Besides damaging the brain, stroke causes systemic changes, including to the
gastrointestinal system. A growing body of evidence supports the role of the gut and its …

Gut microbiota composition is related to AD pathology

BJH Verhaar, HMA Hendriksen, FA de Leeuw… - Frontiers in …, 2022 - frontiersin.org
Introduction Several studies have reported alterations in gut microbiota composition of
Alzheimer's disease (AD) patients. However, the observed differences are not consistent …

Gut dysbiosis promotes preeclampsia by regulating macrophages and trophoblasts

J Jin, L Gao, X Zou, Y Zhang, Z Zheng… - Circulation …, 2022 - Am Heart Assoc
Background: Preeclampsia is one of the leading causes of maternal and perinatal morbidity
and is characterized by hypertension, inflammation, and placental dysfunction. Gut …