Orofacial clefts (OFCs) rank as the second most common congenital birth defect in the
United States after Down syndrome and are the most common head and neck congenital …

Background There has been a longstanding debate about the role of folate in the etiology of
orofacial clefts (OFCs). Studies of different measures of nutritional intake or folate status …

Orofacial clefts (OFCs) are among the most common birth defects and impart a significant
burden on afflicted individuals and their families. It is increasingly understood that many …

Orofacial clefts, including cleft lip and palate (CL/P) and neural tube defects (NTDs) are
among the most common congenital anomalies, but knowledge of the genetic basis of these …

Orofacial clefting is considered one of the commonest birth defects worldwide. It presents as
cleft lip only, isolated cleft palate or cleft lip and palate. The condition has a diverse genetic …

Orofacial clefts (OFCs) have multiple etiologies and likely result from an interplay between
genetic and environmental factors. Within the last decade, studies have implicated specific …

Mutations in SHH and several other genes encoding components of the Hedgehog
signaling pathway have been associated with holoprosencephaly syndromes, with …

Cleft lip with/without cleft palate (CL/P) is one of the most common congenital birth defects,
showing the complexity of both genetic and environmental contributions [eg, maternal …

Orofacial clefts (OFCs) are one of the most common types of structural birth defects. The
etiologies are complicated, involving with genetic, epigenetic, and environmental factors …

Non-syndromic tooth agenesis (ns-TA) is one of the most common dental anomalies
characterized by the congenital absence of at least one permanent tooth (excluding third …